Molecular cloning and sequencing of the rat interleukin-12 p40 gene

被引:0
|
作者
Khalife, J [1 ]
Pierrot, C [1 ]
Cocude, C [1 ]
Cêtre, C [1 ]
Godin, C [1 ]
Capron, A [1 ]
机构
[1] Inst Pasteur, INSERM, U167, Ctr Immunol & Biol Parasitaire, F-59019 Lille, France
关键词
rat; interleukin-12; p40; promoter region; cDNA;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The nucleotide sequences containing the rat interleukin-12 p40 gene was determined. Sequencing revealed the presence of sis exons and five introns, Analysis of the 5' non-coding region showed the presence of several possible sites involved in cytokine gene regulation at the transcriptional level, Comparison of the deduced amino acid sequence of rat IL-12 p40 with that of the mouse and of human p40, showed 92% and 65% identity respectively.
引用
收藏
页码:69 / 73
页数:5
相关论文
共 50 条
  • [1] Avian interleukin-12β (p40):: Cloning and characterization of the cDNA and gene
    Balu, S
    Kaiser, P
    [J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2003, 23 (12): : 699 - 707
  • [2] THE INTERLEUKIN-12 SUBUNIT P40 SPECIFICALLY INHIBITS EFFECTS OF THE INTERLEUKIN-12 HETERODIMER
    MATTNER, F
    FISCHER, S
    GUCKES, S
    JIN, SC
    KAULEN, H
    SCHMITT, E
    RUDE, E
    GERMANN, T
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (09) : 2202 - 2208
  • [3] Astrocytes and microglia produce interleukin-12 p40
    Constantinescu, CS
    Frei, K
    Wysocka, M
    Trinchieri, G
    Malipiero, U
    Rostami, A
    Fontana, A
    [J]. INERLEUKIN 12: CELLULAR AND MOLECULAR IMMUNOLOGY OF AN IMPORTANT REGULATORY CYTOKINE, 1996, 795 : 328 - 333
  • [4] Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo
    Gately, MK
    Carvajal, DM
    Connaughton, SE
    Gillessen, S
    Warrier, RR
    Kolinsky, KD
    Wilkinson, VL
    Dwyer, CM
    Higgins, GF
    Podlaski, FJ
    Faherty, DA
    Familletti, PC
    Stern, AS
    Presky, DH
    [J]. INERLEUKIN 12: CELLULAR AND MOLECULAR IMMUNOLOGY OF AN IMPORTANT REGULATORY CYTOKINE, 1996, 795 : 1 - 12
  • [5] Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits
    Wang, X
    Wilkinson, VL
    Podlaski, FJ
    Wu, CY
    Stern, AS
    Presky, DH
    Magram, J
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1999, 29 (06) : 2007 - 2013
  • [6] Interleukin-12 p40 polymorphism and susceptibility to multiple sclerosis
    Alloza, I
    Heggarty, S
    Goris, A
    Graham, CA
    Dubois, B
    McDonnell, G
    Hawkins, SA
    Carton, H
    Vandenbroeck, K
    [J]. ANNALS OF NEUROLOGY, 2002, 52 (04) : 524 - 525
  • [7] Interleukin-12 p40 gene polymorphism is associated with atopic dermatitis and psoriasis vulgaris
    Tsunemi, Y
    Saeki, H
    Nakamura, K
    Kakinuma, T
    Fujita, H
    Asano, N
    Kishimoto, M
    Tanida, Y
    Mitsui, H
    Tada, Y
    Wakugawa, M
    Torii, H
    Komine, M
    Asahima, A
    Tamaki, K
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 119 (01) : 262 - 262
  • [8] The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12
    Lupardus, Patrick J.
    Garcia, K. Christopher
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2008, 382 (04) : 931 - 941
  • [9] The expression of interleukin-23 (p19/p40) and interleukin-12 (p35/p40) in psoriasis skin
    Chen X.
    Tan Z.
    Yue Q.
    Liu H.
    Liu Z.
    Li J.
    [J]. Journal of Huazhong University of Science and Technology, 2006, 26 (6): : 750 - 752
  • [10] Diagnostic value of interleukin-12 p40 in tuberculous pleural effusions
    Valdes, L.
    Jose, E. San
    Dobano, J. M. Alvarez
    Golpe, A.
    Valle, J. M.
    Penela, P.
    Barcala, F. J. Gonzalez
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2009, 33 (04) : 816 - 820