Prostate-specific membrane antigen in prostate cancer imaging and treatment

被引:7
|
作者
Lim, Emerson [1 ]
机构
[1] Columbia Univ, Irving Med Ctr, Herbert Irving Comprehens Canc Ctr, Div Hematol Oncol, 161 Ft Washington Ave,9th Floor, New York, NY 10033 USA
关键词
Prostate-specific membrane antigen (PSMA); positron emission tomography (PET); prostate cancer imaging; GA-68-LABELED PSMA LIGAND; LYMPH-NODE DISSECTION; RADICAL PROSTATECTOMY; RADIOLIGAND THERAPY; MULTIPARAMETRIC MRI; GA-68-PSMA PET/CT; RADIATION-THERAPY; BIOCHEMICAL RECURRENCE; SALVAGE RADIOTHERAPY; C-11-CHOLINE PET/CT;
D O I
10.21037/tcr.2018.07.04
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Despite the prevalence of prostate cancer (PC), conventional imaging such as computed tomography (CT), magnetic resonance imaging (MRI), and bone scintigraphy have significant limitations in identifying the disease, leading to problems with diagnosis and management. Prostate-specific membrane antigen (PSMA) is a membrane-bound protein that is heavily expressed on PC cells. Radiolabeled antibodies and small molecule inhibitors of PSMA have allowed for imaging with positron emission tomography (PET). These novel PET agents have been studied in a variety of clinical scenarios. Compared to conventional imaging, they are better able to detect localized disease and regional lymph nodes, reveal disease at the time of biochemical recurrence, and identify oligometastatic sites for targeted radiation therapy. While PSMA-PET appears superior to conventional imaging, it also has limitations with sensitivity in certain settings. Additionally, current reports on PSMA-PET imaging in PC are largely retrospective reviews. Well-designed prospective clinical trials should be conducted in order to understand the true potential of this novel imaging modality.
引用
收藏
页码:S676 / S689
页数:14
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