Microvascular Dysfunction Is Associated With Worse Cognitive Performance The Maastricht Study

被引：46

作者：

Rensma, Sytze P. ^{[1
,2
]}

van Sloten, Thomas T. ^{[1
,2
]}

Houben, Alfons J. H. M. ^{[1
,2
]}

Koehler, Sebastian ^{[3
]}

van Boxtel, Martin P. J. ^{[3
,4
]}

Berendschot, Tos T. J. M. ^{[5
]}

Jansen, Jacobus F. A. ^{[3
,6
,10
]}

Verhey, Frans R. J. ^{[3
,4
]}

Kroon, Abraham A. ^{[1
,2
]}

Koster, Annemarie ^{[8
,9
]}

Backes, Walter H. ^{[3
,6
]}

Schaper, Nicolaas ^{[1
,2
,9
]}

Dinant, Geert-Jan ^{[9
]}

Schalkwijk, Casper G. ^{[2
]}

Henry, Ronald M. A. ^{[1
,2
,7
]}

Wolfs, Elze M. L. ^{[2
]}

van Heumen, Mike J. A. ^{[2
]}

Schram, Miranda T. ^{[1
,2
,7
]}

Stehouwer, Coen D. A. ^{[1
,2
]}

机构：

[1] Maastricht Univ, Med Ctr, CARIM Sch Cardiovasc Dis, Maastricht, Limburg, Netherlands

[2] Maastricht Univ, Med Ctr, Dept Internal Med, Maastricht, Limburg, Netherlands

[3] Maastricht Univ, Med Ctr, MHeNs Sch Mental Hlth & Neurosci, Maastricht, Limburg, Netherlands

[4] Maastricht Univ, Med Ctr, Dept Psychiat & Neuropsychol, Maastricht, Limburg, Netherlands

[5] Maastricht Univ, Med Ctr, Dept Ophthalmol, Maastricht, Limburg, Netherlands

[6] Maastricht Univ, Med Ctr, Dept Radiol & Nucl Med, Maastricht, Limburg, Netherlands

[7] Maastricht Univ, Med Ctr, Netherlands Heart & Vasc Ctr, Maastricht, Limburg, Netherlands

[8] Maastricht Univ, Med Ctr, Dept Social Med, Maastricht, Limburg, Netherlands

[9] Maastricht Univ, Med Ctr, Sch Publ Hlth & Primary Care CAPHRI, Maastricht, Limburg, Netherlands

[10] Eindhoven Univ Technol, Dept Elect Engn, Eindhoven, North Brabant, Netherlands

来源：

HYPERTENSION | 2020年 / 75卷 / 01期

关键词：

blood pressure; cerebral small vessel disease; cognition; dilation; hyperemia; hypertension; microcirculation; SMALL VESSEL DISEASE; WHITE-MATTER HYPERINTENSITIES; GENERAL ELDERLY POPULATION; BDNF VAL66MET POLYMORPHISM; PARTICIPANTS AGED 24-81; LOW-GRADE INFLAMMATION; OFFICE BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; NORMATIVE DATA; DEPRESSIVE SYMPTOMS;

D O I：

10.1161/HYPERTENSIONAHA.119.13023

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Microvascular dysfunction may be associated with worse cognitive performance. Most previous studies did not adjust for important confounders, evaluated only individual measures of microvascular dysfunction, and showed inconsistent results. We evaluated the association between a comprehensive set of measures of microvascular dysfunction and cognitive performance in the population-based Maastricht Study. We used cross-sectional data including 3011 participants (age 59.5 +/- 8.2; 48.9% women; 26.5% type 2 diabetes mellitus [oversampled by design]). Measures of microvascular dysfunction included magnetic resonance imaging features of cerebral small vessel disease, plasma biomarkers of microvascular dysfunction, albuminuria, flicker light-induced retinal arteriolar and venular dilation response and heat-induced skin hyperemia. These measures were summarized into a microvascular dysfunction composite score. Cognitive domains assessed were memory, processing speed, and executive function. A cognitive function score was calculated as the sum of the scores on these 3 cognitive domains. The microvascular dysfunction score was associated with a worse cognitive function score (standardized beta, -0.087 [95% CI, -0.127 to -0.047]), independent of age, education level, sex, type 2 diabetes mellitus, smoking, alcohol use, hypertension, total/HDL (high-density lipoprotein) cholesterol ratio, triglycerides, lipid-modifying medication, prior cardiovascular disease, depression and plasma biomarkers of low-grade inflammation. The fully adjusted beta-coefficient of the association between the microvascular dysfunction score and the cognitive function score was equivalent to 2 (range, 1-3) years of aging for each SD higher microvascular dysfunction score. The microvascular dysfunction score was associated with worse memory and processing speed but not with worse executive function. The present study shows that microvascular dysfunction is associated with worse cognitive performance.

引用

页码：237 / 245

页数：9

共 50 条

[1] Microvascular Dysfunction Is Associated with Worse Cognitive Performance: The Maastricht Study
Rensma, Sytze
van Sloten, T. T.
Houben, A. J. H. M.
van Boxtel, M. P. J.
Berendschot, T. T. J. M.
Jansen, J. F. A.
Kroon, A. A.
Koster, A.
Backes, W. H.
Schaper, N.
Dinant, G. J.
Schalkwijk, C. G.
Henry, R. M. A.
Wolfs, E. M. L.
van Heumen, M. J. A.
Schram, M. T.
Stehouwer, C. D. A.
[J]. JOURNAL OF VASCULAR RESEARCH, 2019, 56 : 94 - 94
[2] NEURODEGENERATION, MICROVASCULAR DYSFUNCTION AND THEIR INTERACTION: ASSOCIATIONS WITH COGNITIVE PERFORMANCE - THE MAASTRICHT STUDY
van der Heide, Frank
Henry, Ronald
Houben, Alfons
Kroon, Abraham
van der Kallen, Carla
Dagnelie, Pieter
Schram, Miranda
Eussen, Simone
Berendschot, Tos
Schouten, Jan
Webers, Carroll
Van Greevenbroek, Marleen
Wesselius, Anke
Koster, Annemarie
Savelberg, Hans
Schaper, Nicolaas
Schalkwijk, Casper
van Boxtel, Martin
Kohler, Seb
Stehouwer, Coen
[J]. JOURNAL OF HYPERTENSION, 2022, 40 (SUPPL) : E264 - E264
[3] Associations of Arterial Stiffness With Cognitive Performance, and the Role of Microvascular Dysfunction The Maastricht Study
Rensma, Sytze P.
Stehouwer, Coen D. A.
Van Boxtel, Martin P. J.
Houben, Alfons J. H. M.
Berendschot, Tos T. J. M.
Jansen, Jaap F. A.
Schalkwijk, Casper G.
Verhey, Frans R. J.
Kroon, Abraham A.
Henry, Ronald M. A.
Backes, Walter H.
Dagnelie, Pieter C.
van Dongen, Martin C. J. M.
Eussen, Simone J. P. M.
Bosma, Hans
Kohler, Sebastian
Reesink, Koen D.
Schram, Miranda T.
van Sloten, Thomas T.
[J]. HYPERTENSION, 2020, 75 (06) : 1607 - 1614
[4] Microvascular endothelial dysfunction is associated with albuminuria: the Maastricht Study
Martens, Remy J. H.
Houben, Alfons J. H. M.
Kooman, Jeroen P.
Berendschot, Tos T. J. M.
Dagnelie, Pieter C.
van der Kallen, Carla J. H.
Kroon, Abraham A.
Leunissen, Karel M. L.
van der Sande, Frank M.
Schaper, Nicolaas C.
Schouten, Jan S. A. G.
Schram, Miranda T.
Sep, Simone J. S.
Sorensen, Ben M.
Henry, Ronald M. A.
Stehouwer, Coen D. A.
[J]. JOURNAL OF HYPERTENSION, 2018, 36 (05) : 1178 - 1187
[5] MICROVASCULAR DYSFUNCTION IS ASSOCIATED WITH THE PRESENCE OF ALBUMINURIA - THE MAASTRICHT STUDY
Martens, Remy J. H.
Henry, Ronald M. A.
Houben, Alfon J. H.
van der Kallen, Carla J. H.
Kroon, Abraham A.
Schram, Miranda T.
Sep, Simone J. S.
Schaper, Nicolaas C.
Dagnelie, Pieter C.
Muris, Dennis M. J.
Kooman, Jeroen P.
Stehouwer, Coen D. A.
[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2015, 30
[6] Carotid stiffness is associated with retinal microvascular dysfunction: the Maastricht study
Zhou, T.
van der Heide, F. C. T.
Henry, R. M. A.
Houben, A. J. H.
Kroon, A. A.
van der Kallen, C. J. H.
Dagnelie, P. C.
Eussen, S. J. P.
Berendschot, T. T. J.
Schouten, J. S. A.
Schram, M. T.
van Greevenbroek, M. M. J.
Wesselius, A.
Reesink, K. D.
Stehouwer, C. D. A.
[J]. DIABETOLOGIA, 2019, 62 : S501 - S501
[7] Carotid stiffness is associated with retinal microvascular dysfunction-The Maastricht study
van der Heide, Frank C. T.
Zhou, Tan Lai
Henry, Ronald M. A.
Houben, Alfons J. H. M.
Kroon, Abraham A.
Dagnelie, Pieter C.
van Dongen, Martien C. J. M.
Eussen, Simone J. P. M.
Berendschot, Tos T. J. M.
Schouten, Jan S. A. G.
Webers, Carroll A. B.
Schram, Miranda T.
van Greevenbroek, Marleen M. J.
Wesselius, Anke
Schalkwijk, Casper G.
Koster, Annemarie
Savelberg, Hans H. C. M.
Schaper, Nicolaas C.
Reesink, Koen D.
Stehouwer, Coen D. A.
[J]. MICROCIRCULATION, 2021, 28 (06)
[8] Carotid stiffness is associated with retinal microvascular dysfunction- The Maastricht Study
van der Heide, Frank Cornelis Theodorus
Zhou, Tan Lai
Henry, Ronald
Houben, Alfons
Kroon, Abraham
van der Kallen, Carla
Dagnelie, Pieter
van Dongen, Martien
Eussen, Simone
Berendschot, Tos T. J. M.
Schouten, Jan
Webers, Carroll
Schram, Miranda
van Greevenbroek, Marleen
Reesink, Koen
Stehouwer, Coen D. A.
[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2020, 61 (07)
[9] Markers of Microvascular Dysfunction Are Associated with Incident Depressive Symptoms: The Maastricht Study
Geraets, Anouk
Van Agtmaal, Marnix
Stehouwer, Coen D. A.
Sorensen, Ben
Berendschot, Tos
Schouten, Jan
Schaper, Nicolaas
Henry, Ronald
van der Kallen, Carla
Koster, Annemarie
Eussen, Simone
Kohler, Sebastian
Schram, Miranda T.
Houben, Alfons J. H. M.
[J]. JOURNAL OF VASCULAR RESEARCH, 2019, 56 : 38 - 39
[10] MARKERS OF MICROVASCULAR DYSFUNCTION ARE ASSOCIATED WITH PREVALENT AND INCIDENT DEPRESSIVE SYMPTOMS: THE MAASTRICHT STUDY
Houben, A.
Geraets, A.
van Agtmaal, M.
Stehouwer, C.
Sorensen, B.
Berendschot, T.
Webers, C.
Schaper, N.
Henry, R.
van der Kallen, C.
Koster, A.
Eussen, S.
van Sloten, T.
Koehler, S.
Schram, M.
[J]. JOURNAL OF HYPERTENSION, 2019, 37 : E72 - E72

← 1 2 3 4 5 →