The dual-receptor system of fibroblast growth factors.

被引：0
|
作者：
Zheng, L [1 ]
Liu, C [1 ]
Wang, HX [1 ]
机构：
[1] Acad Mil Med Sci, Inst Basic Med Sci, Beijing 100850, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 1998年 / 25卷 / 02期
关键词：
fibroblast growth factor receptors; heparin sulphate proteoglycans; dual-receptor system;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The activity of fibroblast growth factors (FGFs) is mediated by a dual-receptor system. This comprises a family of four receptor tyrosine kinases (FGFRs) and heparin sulphate proteoglycans (HSPG). The binding of the FGFs to the FGFRSs is marked by a pattern of overlapping specificity despite alternative splicing events generating a large number of FGFRs. HSPG receptors may stimulate the combination between the FGFs and FGFRs, and provide additional specifity allowing a cell to fine tune its response to the FGFs. FGFRs induce the activities of downstream signal molecules which then act in different ways that affect the cell's development, mitogenesis, and neuronal differentation, respectivly.
引用
收藏
页码：122 / 126
页数：5
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