Amide-directed arylation of sp3 C-H bonds using Pd(II) and Pd(0) catalysts

被引：41
|
作者：
Wasa, Masayuki [1 ]
Yu, Jin-Quan [1 ]
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
来源：
TETRAHEDRON | 2010年 / 66卷 / 26期
基金：
美国国家卫生研究院;
关键词：
Amide; Palladium; Arylation; sp(3) C-H activation; ANILIDE ORTHO-ARYLATION; COUPLING REACTIONS; OXIDATIVE FUNCTIONALIZATION; REDUCTIVE ELIMINATION; ARYL; ACTIVATION; ACIDS; SP(2); ALKYLATION; REGIOSELECTIVITY;
D O I：
10.1016/j.tet.2010.03.111
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Protocols to effect beta-arylation of sp(3) C-H bonds via Pd(II)/(IV) and Pd(0)/(II) catalytic cycles have been achieved using a newly developed monodentate CONHC6F5 directing group. These reactions provide an unprecedented means to functionalize sp(3) C-H bonds in aliphatic carboxylic acid-derived substrates. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4811 / 4815
页数：5
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