Expression patterns of the E-cadherin-catenin cell-cell adhesion complex in gastric cancer

被引:0
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作者
Karatzas, G
Karayiannakis, AJ
Syrigos, KN
Chatzigianni, E
Papanikolaou, S
Simatos, G
Papanikolaou, D
Bogris, S
机构
[1] Univ Athens, Sch Med, Propaedeut Dept Surg 2, GR-11527 Athens, Greece
[2] 1st IKA Hosp, Dept Surg 1, Athens, Greece
[3] Univ Athens, Sch Med, Dept Med 1, GR-11527 Athens, Greece
[4] 3rd IKA Hosp, Dept Pathol, Athens, Greece
关键词
cell adhesion; catenin; E-cadherin; gastric cancer; p120;
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aims: The E-cadherin-catenin complex plays a key role in intercellular adhesion of epithelial cells. Aberrant expression and/or function of its components have been implicated in tumor progression and metastasis. We evaluated the expression of the E-cadherin-catenin complex in gastric cancer by immunohistochemistry and investigated its relationship to histopathological features. Methodology: The expression of E-cadherin, alpha-, beta-, and gamma -catenin, and p120 protein was evaluated by immunohistochemistry in 36 formalin-fixed, paraffin-embedded specimens of gastric cancer. Results: In benign gastric mucosa all five molecules co-localized at the cell membrane. Reduced E-cadherin, alpha-, beta-, and gamma -catenin, and p120 expression was found in 67%, 61%, 50%, 64%, and 56% of cases, respectively. The expression of E-cadherin and beta -catenin correlated significantly with the histological type and the degree of tumor differentiation, gamma -Catenin expression correlated only with the histological type of the tumor. The expression of E-cadherin correlated significantly with alpha-, beta- and gamma -catenin, and p120 expression, respectively. The expression of E-cadherin and alpha -catenin showed the highest concordance. Conclusions: In gastric cancer, reduced E-cadherin, gamma -catenin and p120 expressions are related events with E-cadherin showing the most frequent aberrations.
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页码:1465 / 1469
页数:5
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