Risk of residues of toltrazuril sulfone in eggs after oral administration-Could setting maximum residue limit be helpful?

被引：4

作者：

Pietruk, Konrad ^{[1
]}

Olejnik, Malgorzata ^{[2
]}

Jedziniak, Piotr ^{[1
]}

机构：

[1] Natl Vet Res Inst, Dept Pharmacol & Toxicol, 57 Partyzantow Ave, PL-24100 Pulawy, Poland

[2] Nicolaus Copernicus Univ Torun, Fac Biol & Vet Sci, Dept Basic & Preclin Sci, 11 Gagarina St, PL-87100 Torun, Poland

来源：

FOOD CHEMISTRY | 2021年 / 360卷

关键词：

Toltrazuril sulfone; Eggs; Laying hens; Depletion; Withdrawal time; Residue; VETERINARY DRUGS; COCCIDIOSIS; FEED;

D O I：

10.1016/j.foodchem.2021.130054

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A depletion study of toltrazuril and its metabolites was performed using 20 hens medicated via drinking water for two days in a dosage of 7 mg kg- 1 per kg body weight. Afterward, eggs were collected for 42 days. Residues were analyzed in whole eggs and yolk and whites. Toltrazuril sulfone was found to be the most predominant in all matrices, the highest concentration was found in the yolk-5567 & micro;g kg- 1, followed by whole eggs samples-4767 & micro;g kg- 1 and egg whites-532 & micro;g kg- 1. On last day toltrazuril sulfone were still detected-22.5 & micro;g kg- 1. 70 days is required to concentration of toltrazuril sulfone reach zero. Administrating toltrazuril before the laying phase can pose a risk of residues of toltrazuril sulfone in eggs. Setting Maximum Residue Limit could reduce the risk of non-complaint samples and ensure the safety of consumers, but still requires 44 days of the withdrawal period.

引用

页数：5