Thromboprophylaxis using a low molecular weight heparin delays fracture repair

被引：0

作者：

Street, JT ^{[1
]}

McGrath, M ^{[1
]}

O'Regan, K ^{[1
]}

Wakai, A ^{[1
]}

McGuinness, A ^{[1
]}

Redmond, HP ^{[1
]}

机构：

[1] Cork Univ Hosp, Univ Coll Cork, Acad Dept Surg, Orthoped Res Unit, Cork, Ireland

来源：

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH | 2000年 / 381期

关键词：

D O I：

暂无

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Low molecular weight heparins are significantly superior to unfractionated heparin or warfarin in the prevention of thromboembolic episodes associated with orthopaedic surgery. Therapeutic doses of heparin and warfarin have been shown to delay bone repair in a rabbit model. The current study investigated the effect of prophylactic administration of a low molecular weight heparin, enoxaparin, on the healing of a closed rabbit rib fracture. Fracture healing was assessed using histomorphometric, histologic, and immunohistochemical methods at 3, 7, and 14 days, and biomechanical testing with torsional loading was assessed after 21 days. Bone repair was significantly attenuated at all times in animals receiving subcutaneous enoxaparin compared with that of the control animals, Numerous putative mechanisms for this phenomenon are discussed, and additional studies are proposed to elucidate the effects of this pharmacologically diverse group of compounds on an aspects of bone physiology and repair.

引用

页码：278 / 289

页数：12

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