Metal-Free Oxidative Radical Addition of Carbonyl Compounds to α,α-Diaryl Allylic Alcohols: Synthesis of Highly Functionalized Ketones

被引：71

作者：

Chu, Xue-Qiang ^{[1
,2
]}

Meng, Hua ^{[1
,2
]}

Zi, You ^{[1
,2
]}

Xu, Xiao-Ping ^{[1
,2
]}

Ji, Shun-Jun ^{[1
,2
]}

机构：

[1] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

[2] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 51期

关键词：

allylic compounds; 1,2-aryl migration; dicarbonyl compounds; domino reactions; radical reactions; EFFICIENT SYNTHESIS; CATALYZED TRIFLUOROMETHYLATION; BOND FUNCTIONALIZATION; SIMPLE ALKANES; CYCLIC ETHERS; C(SP(3))-H; INSERTION; ALKENES; REARRANGEMENT; ALKENYLATION;

D O I：

10.1002/chem.201404463

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A metal-free direct alkylation of simple carbonyl compounds (ketones, esters, and amides) with alpha,alpha-diaryl allylic alcohols is described. The protocol provides facile access to highly functionalized dicarbonyl ketones by a radical addition/1,2-aryl migration cascade. The regioselectivity of the reaction was precisely controlled by the nature of the carbonyl compound.

引用

页码：17198 / 17206

页数：9

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