Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis

被引：313

作者：

Mukhtar, TA ^{[1
]}

Wright, GD ^{[1
]}

机构：

[1] McMaster Univ, Dept Biochem & Biomed Sci, Antimicrobial Res Ctr, Hamilton, ON L8N 3Z5, Canada

来源：

CHEMICAL REVIEWS | 2005年 / 105卷 / 02期

关键词：

D O I：

10.1021/cr030110z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Up to the present, translation and the ribosome remain outstanding drug targets with a number of efforts directed toward further mining the potential of this ribozyme and associated activities in drug design. Ribosome is still considered a very important drug target. This review covers the structure, mode of action, and resistance to the streptogramin and oxazolidinone antibiotics, two distinct classes of antibiotics recently brought to market for treatment of bacterial infections. It also describes some new and old classes of antibiotics that block translation.

引用

页码：529 / 542

页数：14

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