New antifungal peptides. Synthesis, bioassays and initial structure prediction by CD spectroscopy

被引：13
|
作者：
Olivella, Monica S. [1 ]
Rodriguez, Ana M. [1 ]
Zacchino, Susana A. [2 ]
Somlai, Csaba [3 ]
Penke, Botond [3 ]
Farkas, Victor [4 ]
Perczel, Andras [4 ]
Enriz, Ricardo D. [1 ]
机构：
[1] Univ Nacl San Luis, Fac Quim Bioquim & Farm, RA-5700 San Luis, Argentina
[2] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, RA-2000 Rosario, Santa Fe, Argentina
[3] Univ Szeged, Dept Med Chem, H-6720 Szeged, Hungary
[4] Eotvos Lorand Univ, Inst Chem, HAS ELU Prot Modelling Grp, Budapest, Hungary
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 16期
关键词：
Peptides; Antifungal; Conformation; Circular dichroism; FUNGAL CELL-WALL; IN-VITRO; CONFORMATIONAL PROPERTIES; INHIBITORY PROPERTIES; ANALOGS; DERIVATIVES; PENETRATIN; SERIES;
D O I：
10.1016/j.bmcl.2010.06.105
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis, in vitro evaluation and conformational study of KKWKMRRNQFWIKIQR-NH2, HFRWRQIKIWFQNRRMKWKK-NH2 and RQPKIWFPNRRKPWKK-NH2 acting as antifungal agents are reported. These peptides displayed a moderate but significant antifungal effect against both pathogenic fungi Candida albicans and Cryptococcus neoformans. The conformational analysis of these peptides was carried out using both theoretical and experimental methods. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4808 / 4811
页数：4
相关论文
共 50 条
  • [1] Synthesis of new functional amino acids for designer peptides.
    Berthelot, DJC
    Jones, RCF
    Iley, JN
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 219 : U115 - U115
  • [2] The relation of chemical structure to the rate of hydrolysis of peptides. I. On the synthesis, on the physical constants, and on the rates of hydrolysis of methylated peptides.
    Levene, PA
    Simms, HS
    Pfaltz, MH
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1924, 61 (02) : 445 - 464
  • [3] New reactions of the thiocarbonyl function. The synthesis of hindered peptides.
    Barton, DHR
    Ferreira, JA
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1997, 120 : 1 - 20
  • [4] Combining vibrational spectroscopy and NMR provides an ideal tool for the structure analysis of unfolded peptides.
    Schweitzer-Stenner, Reinhard
    Measey, Thomas J.
    Hagarman, Andrew
    BIOPHYSICAL JOURNAL, 2007, : 358A - 359A
  • [5] New Small-Size Antifungal Peptides: Design, Synthesis and Antifungal Activity
    Garro, Adriana D.
    Garibotto, Francisco M.
    Rodriguez, Ana M.
    Raimondi, Marcela
    Zacchino, Susana A.
    Perczel, Andras
    Somlai, Csaba
    Penke, Botond
    Enriz, Ricardo D.
    LETTERS IN DRUG DESIGN & DISCOVERY, 2011, 8 (06) : 562 - 567
  • [6] New short cationic antibacterial peptides. Synthesis, biological activity and mechanism of action
    Lima, Beatriz
    Ricci, Maria
    Garro, Adriana
    Juhasz, Tunde
    Szigyarto, Imola Csilla
    Papp, Zita, I
    Feresin, Gabriela
    Garcia de la Torre, Jose
    Lopez Cascales, Javier
    Fulop, Livia
    Beke-Somfai, Tamas
    Enriz, Ricardo D.
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2021, 1863 (10):
  • [7] Density functional theory studies of structure and spectroscopy of gold clusters protected by conformationally constrained peptides.
    Gascon, Jose A.
    Perera, Neranjan
    Maran, Flavio
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
  • [8] Synthesis of new antifungal peptides selective against Cryptococcus neoformans
    Grimaldi, Manuela
    De Rosa, Margherita
    Di Marino, Sara
    Scrima, Mario
    Posteraro, Brunella
    Sanguinetti, Maurizio
    Fadda, Giovanni
    Soriente, Annunziata
    D'Ursi, Anna Maria
    BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (22) : 7985 - 7990
  • [9] Secondary structure prediction of disordered proteins by CD spectroscopy
    Micsonai, A.
    Murvai, N.
    Bulyaki, E.
    Szabo, B.
    Wien, F.
    Refregiers, M.
    Lee, Y-H.
    Goto, Y.
    Han, K-H.
    Tompa, P.
    Tantos, A.
    Kardos, J.
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2017, 46 : S395 - S395
  • [10] Synthesis, Spectroscopy Properties and Antifungal Activity of New Quinoxaline Derivatives
    Zhu, Jian-liang
    Chen, Wei-Ting
    Yu, Wei
    Min, Li-Jing
    Ye, Peng
    Hang, Liang
    Wu, Hong-Ke
    Liu, Xing-Hai
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2021, 31 (02) : 215 - 221
12345