Potential Mechanisms Underlying the Therapeutic Effects of Electroconvulsive Therapy

被引：21

作者：

Jiang, Jiangling ^{[1
]}

Wang, Jijun ^{[1
,2
,3
]}

Li, Chunbo ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China

[2] Shanghai Jiao Tong Univ, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, BioX Inst, Shanghai 200030, Peoples R China

[3] Shanghai Jiao Tong Univ, Brain Sci & Technol Res Ctr, Shanghai 200030, Peoples R China

来源：

NEUROSCIENCE BULLETIN | 2017年 / 33卷 / 03期

关键词：

Electroconvulsive therapy; Neurotransmitters; Neurotrophins; Inflammatory factors; Epigenetics; Neuroimaging; MAJOR DEPRESSIVE DISORDER; CEREBRAL-BLOOD-FLOW; ENDOTHELIAL GROWTH-FACTOR; NEURON-SPECIFIC ENOLASE; POSITRON-EMISSION-TOMOGRAPHY; NECROSIS-FACTOR-ALPHA; NEUROTROPHIC FACTOR LEVELS; LATE-LIFE DEPRESSION; TERM-FOLLOW-UP; RECEPTOR-BINDING;

D O I：

10.1007/s12264-016-0094-x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In spite of the extensive application of electroconvulsive therapy (ECT), how it works remains unclear. So far, researchers have made great efforts in figuring out the mechanisms underlying the effect of ECT treatment via determining the levels of neurotransmitters and cytokines and using genetic and epigenetic tools, as well as structural and functional neuroimaging. To help address this question and provide implications for future research, relevant clinical trials and animal experiments are reviewed.

引用

页码：339 / 347

页数：9

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