Copper(II)-catalyzed Domino Reaction of the Acyclic Ketene-(S,S)-Acetals with Diazo Compounds: Convenient Synthesis of Poly-substituted Thiophenes

被引：10

作者：

Sun, Ran ^{[1
]}

Du, Yang ^{[1
]}

Tian, Cui ^{[3
]}

Li, Lei ^{[1
]}

Wang, He ^{[1
]}

Zhao, Yu-Long ^{[2
]}

机构：

[1] Liaoning Shihua Univ, Sch Chem & Mat Sci, Dandong Rd 1, Fushun 113001, Peoples R China

[2] Northeast Normal Univ, Jilin Prov Key Lab Organ Funct Mol Design & Synth, Fac Chem, Changchun 130024, Jilin, Peoples R China

[3] Luzhou Agr Bur, Jiangyang West Rd 4, Luzhou 646000, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 24期

基金：

中国国家自然科学基金;

关键词：

Acyclic ketene-(S; S)-acetals; Diazo compounds; Poly-substituted thiophenes; Domino reaction; Copper catalyst; ALCOHOLIC OXONIUM YLIDE; 3-COMPONENT REACTION; ENANTIOSELECTIVE SYNTHESIS; SULFUR YLIDES; MULTICOMPONENT REACTIONS; REARRANGEMENT REACTIONS; COOPERATIVE CATALYSIS; BIOLOGICAL EVALUATION; ALPHA-DIAZOCARBONYLS; EFFICIENT SYNTHESIS;

D O I：

10.1002/adsc.201901089

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Copper(II)-catalyzed domino reaction between the acyclic ketene-(S,S)-acetals and diazo compounds has been successfully developed. This reaction proceeds through a sequential formation of electrophilic copper carbenoid, sulfur ylide and subsequent C-S bond coupling and cleavage. Notably, the domino reaction features broad the readily available acyclic ketene-(S,S)-acetals scope and provides a new strategy for the synthesis of poly-substituted thiophenes.

引用

页码：5684 / 5689

页数：6

共 24 条

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