Comparative transcriptional profiling of human Merkel cells and Merkel cell carcinoma

被引：5

作者：

Mouchet, Nicolas ^{[1
]}

Coquart, Nolwenn ^{[2
,3
]}

Lebonvallet, Nicolas ^{[2
]}

Le Gall-Ianotto, Christelle ^{[2
]}

Mogha, Ariane ^{[1
]}

Fautrel, Alain ^{[4
]}

Boulais, Nicholas ^{[2
]}

Dreno, Brigitte ^{[5
]}

Martin, Ludovic ^{[6
]}

Hu, Weiguo ^{[7
]}

Galibert, Marie-Dominique ^{[1
]}

Misery, Laurent ^{[2
,3
]}

机构：

[1] Univ Rennes 1, CNRS, Genet & Dev Inst Rennes, UMR6290, Rennes, France

[2] Univ Western Brittany, Lab Neurosci Brest EA4685, Brest, France

[3] Univ Hosp Brest, Dept Dermatol, Brest, France

[4] Univ Rennes 1, Histopathol Platform, Rennes, France

[5] Univ Hosp Nantes, Dept Dermatol, Nantes, France

[6] Univ Hosp Angers, Dept Dermatol, Angers, France

[7] Univ Hosp Brest, Dept Plast Surg, Brest, France

来源：

EXPERIMENTAL DERMATOLOGY | 2014年 / 23卷 / 12期

关键词：

carcinoma; Merkel cell; microarray; microdissection; polyomavirus; POLYOMAVIRUS;

D O I：

10.1111/exd.12546

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Merkel cell carcinoma is believed to be derived from Merkel cells after infection by Merkel cell polyomavirus (MCPyV) and other poorly understood events. Transcriptional profiling using cDNA microarrays was performed on cells from MCPy-negative and MCPy-positive Merkel cell carcinomas and isolated normal Merkel cells. This microarray revealed numerous significantly upregulated genes and some downregulated genes. The extensive list of genes that were identified in these experiments provides a large body of potentially valuable information of Merkel cell carcinoma carcinogenesis and could represent a source of potential targets for cancer therapy.

引用

页码：928 / 930

页数：3

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