The antifungal activity and biotransformation of diisophorone by the fungus Aspergillus niger

被引：22
|
作者：
Kiran, I
Yildirim, HN
Hanson, JR
Hitchcock, PB
机构：
[1] Univ Osmangazi, Dept Chem, TR-26480 Eskisehir, Turkey
[2] Univ Sussex, Dept Chem, Brighton BN1 9QJ, E Sussex, England
来源：
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY | 2004年 / 79卷 / 12期
关键词：
biotransformation; diisophorone; Aspergillus niger; antifungal activity;
D O I：
10.1002/jctb.1130
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The microbial transformation of racemic diisophorone was investigated using the plant pathogen Aspergillus niger as a biocatalyst. Incubation of diisophorone with Aspergillus niger gave 8alpha-hydroxydiisophorone, 10-hydroxydiisophorone and 17-hydroxydiisophorone on the basis of their spectroscopic data including two-dimensional NMR analysis, nOe and an X-ray crystallographic study. The antifungal activity of diisophorone against Aspergillus niger was also examined. (C) 2004 Society of Chemical Industry
引用
收藏
页码：1366 / 1370
页数：5
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