Adolescent HIV treatment in South Africa's national HIV programme: a retrospective cohort study

被引:46
|
作者
Maskew, Mhairi [1 ]
Bor, Jacob [1 ,3 ,4 ]
MacLeod, William [1 ,3 ]
Carmona, Sergio [6 ]
Sherman, Gayle G. [2 ,5 ]
Fox, Matthew P. [1 ,3 ,4 ]
机构
[1] Univ Witwatersrand, Fac Hlth Sci, Sch Clin Med, Hlth Econ & Epidemiol Res Off,Dept Internal Med, Johannesburg, South Africa
[2] Univ Witwatersrand, Fac Hlth Sci, Sch Clin Med, Dept Paediat & Child Hlth, Johannesburg, South Africa
[3] Boston Univ, Sch Publ Hlth, Dept Global Hlth, Boston, MA USA
[4] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
[5] Natl Inst Communicable Dis, Johannesburg, South Africa
[6] Natl Hlth Lab Serv, Johannesburg, South Africa
来源
LANCET HIV | 2019年 / 6卷 / 11期
基金
美国国家卫生研究院;
关键词
ANTIRETROVIRAL THERAPY; INFECTION; CHILDREN; AIDS;
D O I
10.1016/S2352-3018(19)30234-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background The number of South African adolescents receiving HIV care and treatment in South Africa is growing. By use of routinely collected laboratory data from South Africa's National HIV Programme, we aimed to quantify the numbers of adolescents accessing HIV care and treatment over time, characterise the role of perinatal infection in these trends, and estimate proportions of adolescents seeking HIV care and antiretroviral therapy (ART) in South Africa's public sector. Methods We did a retrospective, descriptive cohort study of children and adolescents aged 1-19 years accessing care in South Africa's public sector HIV treatment programme from 2005 to 2016 with a CD4 cell count or viral load recorded in South Africa's National Health Laboratory Service database. We estimated the total number of children and adolescents entering HIV care with a CD4 cell count or viral load test result by calendar period, as well as the proportion in care and receiving ART with at least one viral load test result. We stratified analyses by gender and by whether the patient entered care at younger than 15 years (probably perinatally infected) or at 15-19 years (probably infected in adolescence). Findings We identified 730 882 patients aged 1-19 years at entry to care between Jan 1, 2005, and Dec 31, 2016. 209 205 (54%) of 388 439 patients entering care younger than 15 years and 301 242 (88%) of 342 443 patients entering care aged 15-19 were female. During the study period, the number of virologically monitored patients aged 15-19 years receiving ART increased from 7949 in 2005-08 to 80 918 in 2013-16. 92 783 (66%) of 140 028 patients aged 15-19 years seeking care started ART by 2016, well below UNAID's target of ART for 90% of those diagnosed. We project that the number of adolescents on ART will continue to rise. Interpretation The many adolescents aged 15-19 years receiving ART reflect the ageing of children entering care at ages 1-14 years, and increases in care-seeking among horizontally infected adolescents aged 15-19 years. However, many adolescents seeking care do not start ART, suggesting an urgent need for interventions to increase uptake of ART and improve services for this population. Copyright (C) 2019 Elsevier Ltd. All rights reserved.
引用
收藏
页码:E760 / E768
页数:9
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