Ruthenium(II)-Catalyzed C-H Bond [3+2] Annulation of N-Nitrosoanilines with Alkynes in Water

被引：13
|
作者：
Chen, Xun [1 ]
Cui, Xue [1 ]
Bai, Lili [1 ]
Wang, Ying [1 ]
Xie, Ying [2 ]
Wang, Shuojin [1 ]
Zhai, Ruirui [1 ]
Zhao, Ke [1 ]
Kong, Dulin [1 ]
Li, Youbin [1 ]
机构：
[1] Hainan Med Univ, Sch Pharm, Hainan Key Lab Res & Dev Trop Herbs, Haikou 571199, Hainan, Peoples R China
[2] Sichuan Univ Sci & Engn, Sch Chem & Environm Engn, Zigong 643000, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 8卷 / 12期
基金：
中国国家自然科学基金; 海南省自然科学基金;
关键词：
ruthenium; C-H activation; annulation; water; indoles; EFFICIENT SYNTHESIS; INDOLE SYNTHESIS; ORGANIC-SYNTHESIS; ACTIVATION; FUNCTIONALIZATION; DERIVATIVES; CYCLIZATION; AMIDATION; ACCESS; AGENTS;
D O I：
10.1002/ajoc.201900553
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient Ru-II-catalyzed C-H bond redox-neutral annulation of N-nitrosoanilines with alkynes by employing water as the solvent has been developed. This transformation provides an easy and robust protocol for the synthesis of indoles with a broad range of functional group tolerance and excellent regioselectivity.
引用
收藏
页码：2209 / 2212
页数：4
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