Protective effect of lactoferrin against LPS-induced endotoxemia is mediated by IL-10

被引：0
|
作者：
Zimecki, M [1 ]
Kruzel, M [1 ]
机构：
[1] Polish Acad Sci, Inst Immunol & Expt Therapy, PL-53114 Wroclaw, Poland
来源：
5TH WORLD CONGRESS ON TRAUMA, SHOCK, INFLAMMATION AND SEPSIS: PATHOPHYSIOLOGY, IMMUNE CONSEQUENCES AND THERAPY | 2000年
关键词：
D O I：
暂无
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
The aim of this study was to investigate the mechanism by which lactoferrin (LF) protects against development of LPS-induced endotoxemia in mice. CBA mice were given 5 mg bovine LF intravenously (i.v.) or per os 24 hr prior to i.v. injection of 50 mu g LPS. Two hours after LPS injection mice were bled and serum levels of TNF-alpha, IL-6 and IL-10 were determined. The results showed that LF alone given i.v. or per os increased the production of TNF-alpha, IL-6 and IL-10 to various degrees. Mice treated with LF 24 hr before LPS injection showed a significantly reduced release of TNF-alpha, and to lesser degree IL-6 and IL-10. The protective effect of LF against development of LPS-induced endotoxemia was associated with a significant increase of the IL-10 to TNF-alpha ratio.
引用
收藏
页码：221 / 225
页数：5
相关论文
共 50 条
  • [1] Indomethacin or IL-10 neutralization can reverse the protective effect of TNFα pretreatment against endotoxemia
    Murphey, ED
    Traber, DL
    SHOCK, 1999, 11 : 48 - 48
  • [2] IL-10 protects against LPS-induced liver injury by decreasing proinflammatory cytokines and apoptosis
    Zhong, J
    Deaciuc, IV
    Burikhanov, R
    de Villiers, WJS
    FASEB JOURNAL, 2003, 17 (04): : A253 - A253
  • [3] Adrenaline enhances LPS-induced IL-10 synthesis: evidence for protein kinase A-mediated pathway
    Siegmund, B
    Eigler, A
    Hartmann, G
    Hacker, U
    Endres, S
    INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1998, 20 (1-3): : 57 - 69
  • [4] Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model
    Pils, Marina C.
    Pisano, Fabio
    Fasnacht, Nicolas
    Heinrich, Jan-Michael
    Groebe, Lothar
    Schippers, Angela
    Rozell, Bjoern
    Jack, Robert S.
    Mueller, Werner
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (02) : 443 - 448
  • [5] Lactoferrin decreases LPS-induced mitochondrial dysfunction in cultured cells and in animal endotoxemia model
    Kruzel, Marian L.
    Actor, Jeffrey K.
    Radak, Zsolt
    Bacsi, Attila
    Saavedra-Molina, Alfredo
    Boldogh, Istvan
    INNATE IMMUNITY, 2010, 16 (02) : 67 - 79
  • [6] FGF-21 Elevated IL-10 Production to Correct LPS-Induced Inflammation
    Li, Jun-yan
    Wang, Nan
    Khoso, Mir Hassan
    Shen, Cheng-bin
    Guo, Meng-ze
    Pang, Xin-xin
    Li, De-shan
    Wang, Wen-fei
    INFLAMMATION, 2018, 41 (03) : 751 - 759
  • [7] Protective effect of berberine against LPS-induced injury in the intestine: a review
    Izadparast, Faezeh
    Riahi-Zajani, Bamdad
    Yarmohammadi, Fatemeh
    Hayes, A. Wallace
    Karimi, Gholamreza
    CELL CYCLE, 2022, 21 (22) : 2365 - 2378
  • [8] FGF-21 Elevated IL-10 Production to Correct LPS-Induced Inflammation
    Jun-yan Li
    Nan Wang
    Mir Hassan Khoso
    Cheng-bin Shen
    Meng-ze Guo
    Xin-xin Pang
    De-shan Li
    Wen-fei Wang
    Inflammation, 2018, 41 : 751 - 759
  • [9] Endogenous IL-10 prevents LPS-induced IFNgamma production in the human colonic mucosa
    Jarry, Anne
    Bossard, Celine
    Masson, Damien
    Denis, Marc G.
    Laboisse, Christian L.
    FASEB JOURNAL, 2007, 21 (05): : A589 - A589
  • [10] The inhibitory effect of cyclic AMP-elevating drugs on LPS-induced TNF alpha generation from human monocytes is not mediated by IL-10
    Seldon, PM
    Barnes, PJ
    Giembycz, MA
    BRITISH JOURNAL OF PHARMACOLOGY, 1996, 119 : P159 - P159
12345