Symbiopolyol, a VCAM-1 Inhibitor from a Symbiotic Dinoflagellate of the Jellyfish Mastigias papna

被引：25

作者：

Hanif, Novriyandi ^{[1
]}

Ohno, Osamu ^{[1
]}

Kitamura, Makoto ^{[1
]}

Yamada, Kaoru ^{[1
]}

Uemura, Daisuke ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Sci, Dept Chem, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 07期

关键词：

MARINE DINOFLAGELLATE; CONFIGURATION ANALYSIS; CHEMICAL-STRUCTURES; AMPHIDINOL; HALICHLORINE; ANTIFUNGAL; EXPRESSION;

D O I：

10.1021/np100221k

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A super-carbon-chain compound, symbiopolyol (1a), was isolated from a symbiotic dinoflagellate of the jellyfish Mastigias papua. Although a direct comparison between symbiopolyol (1a) and lineshuiol B has not been completed, symbiopolyol (1a) is suggested to be the enantiomer of lingshuiol B. The structure of la, including its partial relative configuration, was elucidated on the basis of interpretation of spectroscopic data and chemical transformations. This compound exhibited significant inhibitory activity against the expression of VCAM-1 in human umbilical vein endothelial cells (HUVEC).

引用

页码：1318 / 1322

页数：5

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