Cyclosporin A and FK-506 inhibit development of superantigen-potentiated collagen-induced arthritis in mice

被引：8
|
作者：
Takaoka, Y
Nagai, H
Tanahashi, M
Kawada, K
机构：
[1] Gifu Pharmaceut Univ, Dept Pharmacol, Gifu 502, Japan
[2] Gifu Coll Med, Dept Pathol, Seki, Japan
[3] Toray Ind Inc, Basic Res Labs, Kanagawa, Japan
来源：
GENERAL PHARMACOLOGY | 1998年 / 30卷 / 05期
关键词：
T cell; CD25; superantigen; cyclosporin A; FK-506;
D O I：
10.1016/S0306-3623(97)00331-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Staphylococcal enterotoxine B (SEB; superantigen) accelerated the onset of arthritis in mice preimmunized with type II collagen (SEB-potentiated collagen-induced arthritis). Cyclosporin A and FK-506 inhibited the induction and development of clinical signs and histopathological changes of SEB potentiated collagen-induced arthritis in mice. 2. Simultaneously, both cyclosporin A and FK-506 inhibited the development of humoral and cellular immunity to type II collagen. 3. The expression of IL-2 receptor (CD25) by SEB on splenocyte T cells from collagen-preimmunized mice was inhibited by both agents in ex vivo experimentation. (C) 1998 Elsevier Science Inc.
引用
收藏
页码：777 / 782
页数：6
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