Chromeno[2,3-d]pyrimidine-triones Synthesis by a Three-Component Coupling Reaction

被引：26

作者：

Ghahremanzadeh, Ramin ^{[1
,2
]}

Fereshtehnejad, Fatemeh ^{[1
]}

Bazgir, Ayoob ^{[1
]}

机构：

[1] Shahid Beheshti Univ, Dept Chem, Tehran 1983963113, Iran

[2] ACECR, Avicenna Res Inst, Nanobiotechnol Res Ctr, Tehran 196151177, Iran

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 04期

关键词：

chromeno[2,3-d]pyrimidine; cyclohexane-1,3-dione; barbituric acid; aldehyde; ONE-POT SYNTHESIS; IMMUNODEFICIENCY-VIRUS TYPE-1; EFFICIENT SYNTHESIS; DERIVATIVES; MICROWAVE; AGENTS; CYCLIZATION;

D O I：

10.1248/cpb.58.516

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A simple and one-pot synthesis of new chromeno[2,3-d]pyrimidine-triones by a three-component condensation reaction of barbituric acids, aldehydes and cyclohexane-1,3-diones in refluxing ethanol in the presence of p-toluenesulfonic acid (p-TSA) for 3-10 h is reported. Two cyclohexane-1,3-diones, four barbituric acids and six substituted aldehydes were chosen for the library validation. Prominent among the advantages of this new method are operational simplicity, good yields and easy work-up procedures employed.

引用

页码：516 / 520

页数：5

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