Synthetic Lethal Networks for Precision Oncology: Promises and Pitfalls

被引：15

作者：

Shen, John Paul ^{[1
]}

Ideker, Trey

机构：

[1] 9500 Gilman Dr, San Diego, CA 92101 USA

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2018年 / 430卷 / 18期

基金：

美国国家卫生研究院;

关键词：

synthetic lethal; cancer genomics; precision medicine; systems biology; genetic interaction; OLAPARIB MAINTENANCE THERAPY; SEROUS OVARIAN-CANCER; GENETIC INTERACTIONS; SACCHAROMYCES-CEREVISIAE; MUTUAL EXCLUSIVITY; DOSAGE LETHALITY; MAMMALIAN-CELLS; MUTATION STATUS; SCREEN REVEALS; DNA-REPAIR;

D O I：

10.1016/j.jmb.2018.06.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthetic lethal interactions, in which the simultaneous loss of function of two genes produces a lethal phenotype, are being explored as a means to therapeutically exploit cancer-specific vulnerabilities and expand the scope of precision oncology. Currently, three Food and Drug Administration-approved drugs work by targeting the synthetic lethal interaction between BRCA1/2 and PARP. This review examines additional efforts to discover networks of synthetic lethal interactions and discusses both challenges and opportunities regarding the translation of new synthetic lethal interactions into the clinic. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：2900 / 2912

页数：13

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