Effect of Vitamin E on Uterine Myometrium of Adult Female Albino Rats Treated With Fluoxetine

Background: Vitamin E is well known for its antioxidant property and has potential role in treatment of infertility. Fluoxetine is an antidepressant from SSRI group having effect on reproductive organs by increasing oxidative stress. Aim: To explore the role of vitamin E on uterine myometrium after treatment with fluoxetine Methods: 8-12 weeks old female rats albino of wistar strain (n=10) were divided into three groups Group A (control), group B (experimental) and group C (protective) and were treated with distilled water, oral fluoxetine (80mg/kg) and oral fluoxetine along with vitamin E simultaneously (80mg/kg and 250mg/kg) respectively for 15 days. Gross and histological examination of uterine horns of all rats along with measurement of serum prolactin level was done on 15th day. Mean +/- SD, One-way ANOVA and fisher exact test was applied to analyze data Results: Weight, volume of uterus, utero-somatic index, serum prolactin level and myometrial thickness was signigicantly increased (P value=0.001) along with prescence of adenomyosis in experimental group B which was given fluoxetine alone. however its was observed that in group C which was given vitamin E along with fluoxetine, ameliorated these changes and results were comparable with control group A. Conclusion: Vitamin E has a role in protection of reproductive organs owing to its antioxidant properties when administered along with fluoxetine which produces oxidative stress related changes serum prolactin levels and uterine myometrium.