GREEN SYNTHESIS OF SOME NEW (SUBSTITUTED FLUOROBENZOYLIMINO)-3-ARYL-4-METHYL-1,3-THIAZOLINES

被引：2
|
作者：
Saeed, Aamer [1 ]
Shaheen, Uzma [1 ]
机构：
[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan
来源：
SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 04期
关键词：
Fluorobenzoylimino-1; 3-thiazolines; green synthesis; CRYSTAL-STRUCTURE; DERIVATIVES; WATER; INHIBITORS; DISCOVERY; RECEPTOR; MICE;
D O I：
10.1080/00397910903004381
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 2-, 3-, and 4-substituted (fluorobenzoylimino)-3-aryl-4-methyl-1,3-thiazolines (2a-j) were synthesized in good yields by the base-catalyzed cyclization of corresponding 1-(fluorobenzoyl)-3-(fluorophenyl)thioureas (1a-j) with -bromoacetone in water. Compared to the reactions in conventional nonaqueous solvents under inert anhydrous conditions, the aqueous medium provides a much cleaner, more efficient, and simpler method for synthesis.
引用
收藏
页码：564 / 569
页数：6
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