LACK OF ASSOCIATION BETWEEN SERUM IL-25 LEVELS AND ACUTE CORONARY SYNDROME: A PRELIMINARY STUDY

Purpose Here, for the first time, the possible association between IL-25 and the risk of acute coronary syndrome (ACS) in Iranian patients was investigated. Material and methods In this study, serum IL-25 concentrations were measured with an enzyme-linked immunosorbent assay in 88 ACS patients, 40 stable angina pectoris (SAP) patients, and 50 healthy control subjects. Results No significant differences in IL-25 concentrations were observed between SAP (340 +/- 168 ng/l), ACS (330 +/- 151 ng/l), and control (302 +/- 135 ng/l) groups (p=0.5), nor was there a difference among patients with 1, 2, or 3 vessel disease in the SAP and ACS groups. Linear regression analyses revealed that IL-25 was not correlated with coronary artery disease risk factors. Biochemical and demographic variables did not differ significantly among IL-25 quartiles. Conclusion Despite previous murine and human studies showing a protective role of IL-25 in atherosclerosis, our results revealed that IL-25 does not have potential implications for atherosclerosis development and management in humans.