Association between APOE gene and myocardial bridge in Chinese Han population: a case-control study

Studies found that APOE gene play an important role in the development of cardiovascular disease. To investigate the genetic association between myocardial bridge (MB) and APOE gene, we conducted this case-control study and genotyped 5 SNPs using ligase detection reaction in 419 patients and 504 controls. The results indicated that, in total group, rs405509, rs769450, rs439401, rs7259004 and rs2075650 showed no significant association with myocardial bridge. The p value are all more than 0.05 and the OR [95% CI] value all included "1", both in the allele analysis and in the genotype analysis. In both the female-subgroup and male-subgroup, when subdivided by genders, these 5 SNPs showed no significant association with myocardial bridge. Linkage disequilibrium (expressed in D' and r(2)) for APOE in the Chinese cases and controls are demonstrated and according to the results of Linkage disequilibrium, the haplotype of the first 3 SNPs (rs405509, rs769450, rs439401) in the first block were analyzed. This is the first case-control association study on APOE gene and myocardial bridge. Considering the size of our sample sets (power > 90%), our results suggest that the APOE gene may not play a major role in myocardial bridge in the Chinese Han population.