The Toxoplasma Parasitophorous Vacuole: An Evolving Host-Parasite Frontier

被引：85
|
作者：
Clough, Barbara [1 ]
Frickel, Eva-Maria [1 ]
机构：
[1] Francis Crick Inst, Hosttoxoplasma Interact Lab, 1 Midland Rd, London NW1 1AT, England
来源：
TRENDS IN PARASITOLOGY | 2017年 / 33卷 / 06期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
DENSE GRANULE PROTEIN; GONDII RHOPTRY PROTEIN; PATHOGEN-CONTAINING VACUOLES; IMMUNITY-RELATED GTPASES; IRG RESISTANCE GTPASES; CELL PLASMA-MEMBRANE; GAMMA-INTERFERON; INTRACELLULAR PARASITE; ANTIMICROBIAL ACTIVITY; GENETIC DIVERSITY;
D O I：
10.1016/j.pt.2017.02.007
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The parasitophorous vacuole is a unique replicative niche for apicomplexan parasites, including Toxoplasma gondii. Derived from host plasma membrane, the vacuole is rendered nonfusogenic with the host endolysosomal system. Toxoplasma secretes numerous proteins to modify the forming vacuole, enable nutrient uptake, and set up mechanisms of host subversion. Here we describe the pathways of host-parasite interaction at the parasitophorous vacuole employed by Toxoplasma and host, leading to the intricate balance of host defence versus parasite survival.
引用
收藏
页码：473 / 488
页数：16
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