The chick embryo chorioallantoic membrane (CAM) assay

被引：140

作者：

Ribatti, Domenico ^{[1
,2
]}

机构：

[1] Univ Bari, Med Sch, Dept Basic Med Sci Neurosci & Sensory Organs, Policlin Piazza G Cesare 11, I-70124 Bari, Italy

[2] Natl Canc Inst Giovanni Paolo II, Bari, Italy

来源：

REPRODUCTIVE TOXICOLOGY | 2017年 / 70卷

关键词：

Angiogenesis; Anti-angiogenesis; Chorioallantoic membrane; Tissue grafts; Toxicology; tumor growth; CELL INTRAVASATION; MODEL SYSTEM; ANGIOGENESIS; GROWTH; MICROCIRCULATION; INDUCTION; LINEAGES; ONTOGENY; INVASION; TISSUES;

D O I：

10.1016/j.reprotox.2016.11.004

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During avian development the mesodermal layers of the allantois and chorion fuse to form the chorioallantoic membrane (CAM). This structure rapidly expands generating a rich vascular network that provides an interface for gas and waste exchange. The CAM allows to study tissue grafts, tumor growth and metastasis, drugs delivery and toxicologic analysis, and angiogenic and anti-angiogenic molecules. The CAM is relatively simple, quick, and low-cost model that allows screening of a large number of pharmacological samples in a short time; does not require administrative procedures for obtaining ethics committee approval for animal experimentation. Moreover, being naturally immunodeficient, the chick embryo may receive transplantations from different tissues and species, without immune responses. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：97 / 101

页数：5

共 50 条

[1] Effect of aliskiren on angiogenesis in chick embryo chorioallantoic membrane (CAM) assay
Raul de la Fuente, E.
Carlos Rosas, C.
Marcela Fuenzalida, B.
Hector Rodriguez, B.
Roa, Ignacio
David Lemus, A.
[J]. INTERNATIONAL JOURNAL OF MORPHOLOGY, 2016, 34 (04): : 1191 - 1196
[2] CHORIOALLANTOIC MEMBRANE (CAM) OF CHICK EMBRYO ASSAY TO AQUEOUS EXTRACT OF PTERIDIUM AQUILINUM EVALUATION
Leitolis, Amanda
de Souza, Fernanda Gimenez
Freitas, Kelli
Moledo, Ricardo Andrukaitis
Maracci, Lucas
Franco, Joceline
Pereira, Luiz Fernando
[J]. PHARMACEUTICAL BIOLOGY, 2012, 50 (05) : 561 - 562
[3] The chick embryo chorioallantoic membrane (CAM). A multifaceted experimental model
Ribatti, Domenico
[J]. MECHANISMS OF DEVELOPMENT, 2016, 141 : 70 - 77
[4] Use of the Chick Embryo Chorioallantoic Membrane (CAM) Model in Uveal Melanoma
Oliver, C.
Alexander, J.
Kalirai, H.
Coupland, S. E.
[J]. JOURNAL OF PATHOLOGY, 2019, 248 : S21 - S21
[5] THE EFFECT OF MINOXIDIL ON ANGIOGENESIS ON THE CHORIOALLANTOIC MEMBRANE (CAM) OF THE CHICK-EMBRYO
CHERRY, GW
HOHWU, E
MOLLER, M
RYAN, TJ
[J]. INTERNATIONAL JOURNAL OF MICROCIRCULATION-CLINICAL AND EXPERIMENTAL, 1987, 5 (04): : 397 - 397
[6] The Chick Embryo Chorioallantoic Membrane as an In Vivo Assay to Study Antiangiogenesis
Ribatti, Domenico
[J]. PHARMACEUTICALS, 2010, 3 (03): : 482 - 513
[7] THE CHICK EMBRYO CHORIOALLANTOIC MEMBRANE ASSAY AS A MODEL FOR THE STUDY OF ANGIOGENESIS
Lemos do Prado, Angelica Daiane
Luiz Cardoso Bailao, Elisa Flavia
Nabout, Joao Carlos
Rabachini, Tatiana
de Melo Reis, Paulo Roberto
Goncalves, Pablo Jose
Almeida, Luciane Madureira
[J]. BIOSCIENCE JOURNAL, 2019, 35 (04): : 1262 - 1275
[8] Determination of the LD50 with the chick embryo chorioallantoic membrane (CAM) assay as a promising alternative in nanotoxicological evaluation
Buhr, Christoph Raphael
Eckrich, Jonas
Kluenker, Martin
Bruns, Kai
Wiesmann, Nadine
Tremel, Wolfgang
Brieger, Jurgen
[J]. NANOTOXICOLOGY, 2021, 15 (05) : 690 - 705
[9] ANGIOSTATIC ACTIVITY AND METABOLISM OF CORTISOL IN THE CHORIOALLANTOIC MEMBRANE (CAM) OF THE CHICK-EMBRYO
MCNATT, LG
LANE, D
CLARK, AF
[J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1992, 42 (07): : 687 - 693
[10] New model for the study of angiogenesis and antiangiogenesis in the chick embryo chorioallantoic membrane: The gelatin sponge/chorioallantoic membrane assay
Ribatti, D
Gualandris, A
Bastaki, M
Vacca, A
Iurlaro, M
Roncali, L
Presta, M
[J]. JOURNAL OF VASCULAR RESEARCH, 1997, 34 (06) : 455 - 463

← 1 2 3 4 5 →