Solid-phase synthesis of benzazoles, quinazolines, and quinazolinones using an alkoxyamine linker

被引：7

作者：

Yamaguchi, Kota ^{[1
]}

Noda, Takeshi ^{[2
]}

Higuchi, Yusuke ^{[1
]}

Aoki, Naoyuki ^{[1
]}

Yamaguchi, Rika ^{[1
]}

Kubo, Miwa ^{[3
]}

Harada, Kenichi ^{[3
]}

Fukuyama, Yoshiyasu ^{[3
]}

Hioki, Hideaki ^{[1
]}

机构：

[1] Gunma Univ, Fac Educ, Maebashi, Gunma 3718510, Japan

[2] Kanagawa Inst Technol, Dept Appl Biosci, Atsugi, Kanagawa 2430292, Japan

[3] Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 42期

关键词：

Solid-phase synthesis; Alkoxyamine Linker; Benzimidazole; Quinazoline; Quinazolinone; COMBINATORIAL SYNTHESIS; SINGLE-LAYER; BENZOTHIAZOLES; HETEROCYCLES; OLEDS; HOSTS; BLUE;

D O I：

10.1016/j.tetlet.2014.08.095

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An alkoxyamine linker was applied for the solid-phase synthesis of benzazoles, quinazolines, and quinazolinones. Aromatic aldehydes were anchored by aldoxime linkage. After some reactions on a solid support, the products were cleaved with paraformaldehyde under the acidic conditions to afford the corresponding aldehydes, which were subsequently subjected to oxidative coupling with 2-substituted anilines under air atmosphere to give the desired compounds. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：5793 / 5797

页数：5

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