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- [1] Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mappingScientific Reports, 8Nelda AntonovaiteSteven V. BeekmansElly M. HolWytse J. WadmanDavide Iannuzzi
Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping
被引：70
|作者：
Antonovaite, Nelda
[1
,2
]
Beekmans, Steven V.
[1
,2
]
Hol, Elly M.
[3
,4
,5
]
Wadman, Wytse J.
[5
]
Iannuzzi, Davide
[1
,2
]
机构：
[1] Vrije Univ Amsterdam, Dept Phys & Astron, De Boelelaan 1085, NL-1081 HV Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, LaserLab Amsterdam, De Boelelaan 1085, NL-1081 HV Amsterdam, Netherlands
[3] Univ Med Ctr Utrecht, Dept Translat Neurosci, Brain Ctr Rudolf Magnus, NL-3584 CG Utrecht, Netherlands
[4] Netherlands Inst Neurosci, NL-1105 BA Amsterdam, Netherlands
[5] Univ Amsterdam, Swammerdam Inst Life Sci, Ctr Neurosci, NL-1098 XH Amsterdam, Netherlands
来源：
基金：
欧洲研究理事会;
关键词：
MECHANICAL-PROPERTIES;
NERVOUS-SYSTEM;
WHITE-MATTER;
RAT-BRAIN;
IN-VITRO;
MODELS;
GROWTH;
MATURATION;
BEHAVIOR;
TENSION;
D O I：
10.1038/s41598-018-31035-y
中图分类号：
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号：
07 ;
0710 ;
09 ;
摘要：
The mechanical properties of brain tissue play a pivotal role in neurodevelopment and neurological disorders. Yet, at present, there is no consensus on how the different structural parts of the tissue contribute to its stiffness variations. Here, we have gathered depth-controlled indentation viscoelasticity maps of the hippocampus of acute horizontal live mouse brain slices. Our results confirm the highly viscoelestic nature of brain tissue. We further show that the mechanical properties are non-uniform and at least related to differences in morphological composition. Interestingly, areas with higher nuclear density appear to be softer than areas with lower nuclear density.
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页数：11
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