Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

被引:1
|
作者
Zhang, Manman [1 ,2 ]
Gao, Junling [3 ]
Xie, Bingjiao [2 ]
Mak, Henry Ka Fung [4 ]
Cheung, Raymond Tak Fai [2 ,5 ]
机构
[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurol, Wenzhou, Peoples R China
[2] Univ Hong Kong, Dept Med, Hong Kong, Peoples R China
[3] Univ Hong Kong, Ctr Buddhist Studies, Hong Kong, Peoples R China
[4] Univ Hong Kong, Dept Diagnost Radiol, Hong Kong, Peoples R China
[5] Univ Hong Kong, Res Ctr Heart Brain Hormone & Hlth Aging, Hong Kong, Peoples R China
来源
关键词
WHITE-MATTER HYPERINTENSITIES; CEREBRAL MICROBLEEDS; DECLINE; DEMENTIA; LACUNES; ATROPHY;
D O I
10.3791/61017
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Evidence accumulated from the last decade has proven that silent cerebrovascular lesions (SCLs) and their underlying pathogenic processes contribute to cognitive decline in the elderly. However, the distinct effects of each type of the lesions on cognitive performance remain unclear. Moreover, research data from Chinese elderly with SCLs is scarce. In this study, 398 otherwise healthy hypertensive elderly subjects (median age 72 years) were included and assessed. All participates were required to complete a battery of structured neuropsychological assessment, including forward and backward digit span tests, symbol digit modalities test, Stroop test, verbal fluency test and Montreal Cognitive Assessment. These tests were used to assess attention, executive function, information processing speed, language, memory and visuospatial function. A multi-sequence 3T MRI scanning was arranged within one month of the neuropsychological assessment to evaluate the burden of SCLs. SCLs were rated visually. Cerebral microbleeds (CMBs) and silent lacunes (SLs) were identified as strictly lobar CMBs and SLs or deep CMBs and SLs according to their locations, respectively. Similarly, white matter hyperintensities (WMHs) were separated into periventricular WMHs (PVHs) and deep WMHs (DWMHs). A series of linear regression models were used to assess the correlation between each type of SCLs and individual cognitive function domain. The results showed that CMBs tend to impair languagerelated cognition. Deep SLs affect executive function, but this association disappeared after controlling for other types of SCLs. PVHs, rather than DWMHs, are associated with cognitive decline, especially in executive function and processing speed. It is concluded that different aspects of SCLs have differential impact on cognitive performance in hypertensive elderly Chinese.
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页数:15
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