Recent advances in chemical library synthesis methodology

被引：0

作者：

Flynn, DL ^{[1
]}

Berk, SC ^{[1
]}

Makara, GM ^{[1
]}

机构：

[1] NeoGenesis Pharmaceut Inc, Cambridge, MA 02139 USA

来源：

CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT | 2002年 / 5卷 / 04期

关键词：

chemical library; chemical tagging; phase trafficking; polymer-supported catalysts; polymersupported reactants; polymer-supported reagents; sequestrants; sequestration enabling reagents;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The first part of this review highlights recent advances in polymer-supported reagents, catalysts, reactants and sequestrants. Particular attention is given to recent advances in polymer-supported oxidants, transition metal catalysts and polymer-supported reactants, including acyl groups, guanidinyl groups' alkyl groups and various classes of nucleophiles. This second part of the review highlights recent advances made in the areas of chemical tagging and phase-trafficking techniques, all of which have enabled further advances in the methodology of solution-phase chemical library synthesis.

引用

页码：580 / 593

页数：14

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