The inflammatory mediator oncostatin M induces angiopoietin 2 expression in endothelial cells in vitro and in vivo

被引：31
|
作者：
Rychli, K. [1 ]
Kaun, C. [1 ]
Hohensinner, P. J. [1 ]
Rega, G. [1 ]
Pfaffenberger, S. [1 ]
Vyskocil, E. [1 ]
Breuss, J. M. [2 ]
Furnkranz, A. [3 ]
Uhrin, P. [2 ]
Zaujec, J. [2 ]
Niessner, A. [1 ]
Maurer, G. [1 ]
Huber, K. [3 ]
Wojta, J. [1 ]
机构：
[1] Med Univ Vienna, Dept Internal Med 2, A-1090 Vienna, Austria
[2] Med Univ Vienna, Dept Vasc Biol & Thrombosis Res, A-1090 Vienna, Austria
[3] Wilhelminen Hosp, Med Dept Cardiol & Emergency Med 3, Vienna, Austria
来源：
JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2010年 / 8卷 / 03期
基金：
奥地利科学基金会;
关键词：
angiogenesis; angiopoietin; cytokine; oncostatin M; LEUKEMIA INHIBITORY FACTOR; GROWTH-FACTOR; PLASMINOGEN-ACTIVATOR; PLASMA ANGIOPOIETIN-1; SIGNAL TRANSDUCER; RECEPTOR TIE-2; SMOOTH-MUSCLE; ANGIOGENESIS; INTERLEUKIN-6; LIGAND;
D O I：
10.1111/j.1538-7836.2010.03741.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives: Members of the glycoprotein 130 (gp130) receptor-gp130 ligand family play a role in angiogenesis in different tissues. We tested the effect of this cytokine family on the angiopoietin (Ang)-Tie system, which is involved in blood vessel maturation, stabilization, and regression. Results: Oncostatin M (OSM) increased Ang2 expression in human umbilical vein endothelial cells via Janus kinase/signal transducer and activator of transcription (JAK/STAT) and mitogen-activated protein (MAP) kinase activation. Furthermore, OSM induced Ang2 expression in macrovascular endothelial cells isolated from the human aorta and in microvascular endothelial cells isolated from human heart. Our in vivo experiments revealed that mRNA expression of Ang2 in hearts of mice injected with OSM increased significantly, and levels of OSM mRNA significantly correlated with mRNA levels of Ang2 in human hearts. In addition, OSM increased the expression of its own receptors, gp130 and OSM receptor, in endothelial cells in vitro and in mice in vivo, and levels of OSM mRNA significantly correlated with mRNA levels of gp130 and OSM receptor in human hearts. Conclusion: Our data, showing the effects of OSM on the Ang-Tie system in endothelial cells, in hearts of mice, and in human heart tissue, provide yet another link between inflammation and angiogenesis.
引用
收藏
页码：596 / 604
页数：9
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