Association between air pollution and outpatient visits for allergic rhinitis: Effect modification by ambient temperature and relative humidity

Mounting evidence indicated the associations between air pollution and outpatient visits for allergic rhinitis (AR), while few studies assessed the effect modification of these associations by ambient temperature and relative humidity (RH). In this study, dataset of AR outpatients was obtained from Chinese People's Liberation Army Strategic Support Force Characteristic Medical Center in Beijing during 2014 to 2019, and the average concentrations of air pollutants including particulate matter <= 2.5 mu m in diameter (PM2.5) and <= 10 mu m (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), and meteorological factors (temperature and RH) at the same period were collected from one nearby air mon-itoring station. We performed a time-series study with Poisson regression model to examine the effects of air pollutants on AR outpatients after adjustment for potential confounders. And the effects modification analysis was further con-ducted by stratifying temperature and RH by tertiles into three groups of low, middle and high. In total of 33,599 out-patient visits for AR were recorded during the study period. Results found that a 10 mu g/m(3) increase in PM2.5, PM10, NO2 and SO2 was associated with significant increases in AR outpatients of 1.24% (95% confidence interval (CI): 0.69%, 1.78%), 0.79% (95% CI: 0.43%, 1.15%), 3.05% (95% CI: 1.72%, 4.40%) and 5.01% (95% CI: 1.18%, 8.96%), respectively. Stronger associations were observed in males than those in females, as well as in young adults (18-44 years) than those in other age groups. Air pollution effects on AR outpatients increased markedly at low tem-perature (33.3th percentile) and high RH ( 66.7th percentile). Findings in this study indicate that air pollution is as-sociated with increased risk of AR outpatients, and the effects of air pollution on AR could be enhanced at low temperature and high RH.