Evaluation of occupancy of cannabinoid CB1 receptors by a novel antagonist drug with [11C]OMAR and PET

被引:0
|
作者
Wong, Dean F. [1 ]
Kuwabara, Hiroto [1 ]
Hussain, Babar [1 ]
Horti, Andrew [1 ]
Brasic, Jim [1 ]
Raymont, Vanessa [1 ]
Ye, Weigo [1 ]
Guevara, Maria [1 ]
Cascella, Nicola [2 ]
机构
[1] Johns Hopkins Univ, Dept Radiol, Baltimore, MD 21218 USA
[2] Johns Hopkins Univ, Dept Psychiat, Baltimore, MD 21218 USA
关键词
D O I
10.1016/j.neuroimage.2010.04.049
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
引用
收藏
页码:S64 / S64
页数:1
相关论文
共 50 条
  • [1] Quantification of cerebral cannabinoid receptors subtype 1 (CB1) in healthy subjects and schizophrenia by the novel PET radioligand [11C]OMAR
    Wong, Dean
    Kuwabara, Hiroto
    Horti, Andrew
    Raymont, Vanessa
    Brasic, James
    Guevara, Maria
    Nandi, Ayon
    Rahmim, Arman
    Ming, Jeffrey
    Cascella, Nicola
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2010, 51
  • [2] Quantification of cerebral cannabinoid receptors subtype 1 (CB1) in healthy subjects and schizophrenia by the novel PET radioligand [11C]OMAR
    Wong, Dean F.
    Kuwabara, Hiroto
    Horti, Andrew G.
    Raymont, Vanessa
    Brasic, James
    Guevara, Maria
    Ye, Weiguo
    Dannals, Robert F.
    Ravert, Hayden T.
    Nandi, Ayon
    Rahmim, Arman
    Ming, Jeffrey E.
    Grachev, Igor
    Roy, Christine
    Cascella, Nicola
    [J]. NEUROIMAGE, 2010, 52 (04) : 1505 - 1513
  • [3] PET Imaging of cannabinoid CB1 type receptors in healthy humans and patients with schizophrenia using [11C]OMAR
    Wong, Dean F.
    Kuwabara, H.
    Horti, A.
    Kumar, A.
    Brasic, J.
    Ye, W.
    Alexander, M.
    Raymont, V.
    Galecki, J.
    Charlotte, M.
    Cascella, N.
    [J]. NEUROIMAGE, 2008, 41 : T51 - T51
  • [4] Initial evaluation of [11C] SD5024, a novel PET radioligand for imaging human brain cannabinoid CB1 receptors
    Tsujikawa, Tetsuya
    Zoghbi, Sami
    Hong, Jinsoo
    Donohue, Sean
    Halldin, Christer
    Pike, Victor
    Innis, Robert
    Fujita, Masahiro
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2012, 53
  • [5] Modeling analysis of the CB1 PET tracer [11C]OMAR in rhesus monkeys and humans
    Normandin, Marc D.
    Weinzimmer, David P.
    Ropchan, Jim
    Labaree, David
    Lin, Kuo-Shyan
    Mason, Neale S.
    Carson, Richard E.
    D'Souza, Deepak C.
    Neumeister, Alexander
    Huang, Yiyun
    [J]. NEUROIMAGE, 2010, 52 : S13 - S13
  • [6] Kinetic modeling of CB1 PET tracer [11C]OMAR in rhesus monkeys and humans
    Normandin, Marc
    Weinzimmer, David
    Ropchan, Jim
    Labaree, David
    Lin, Kuo-Shyan
    Mason, Neale
    Carson, Richard
    D'Souza, Deepak
    Neumeister, Alexander
    Huang, Yiyun
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2010, 51
  • [7] Quantification of human brain cannabinoid CB1 receptors using a novel PET radioligand, [11C]SD5024
    Tsujikawa, Tetsuya
    Zoghbi, Sami
    Hong, Jinsoo
    Donohue, Sean
    Halldin, Christer
    Pike, Victor
    Innis, Robert
    Fujita, Masahiro
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2012, 32 : S133 - S134
  • [8] RADIOSYNTHESIS OF [11C]A000571499, A NOVEL SELECTIVE CB1 ANTAGONIST
    Dolle, F.
    Hinnen, F.
    Bigot, A.
    Castel, M.
    Roy, C.
    Deverre, J.
    Bottlaender, M.
    [J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2009, 52 : S361 - S361
  • [9] Imaging the cannabinoid CB1 receptor in humans with [11C]OMAR: Test-retest reproducibility and gender differences
    Normandin, Marc D.
    Zheng, Ming-Qiang
    Ropchan, Jim R.
    Labaree, David
    Najafzadeh, Soheila
    Hull, Rachel
    Qian, Wei
    Henry, Shannan
    Williams, Wendol A.
    Carson, Richard E.
    Huang, Yiyun
    Neumeister, Alexander
    [J]. NEUROIMAGE, 2010, 52 : S82 - S83
  • [10] Synthesis of [11C]OMAR and its analog radioligands for PET imaging of CB1 receptor in brain diseases
    Gao, Mingzhang
    Wang, Min
    Zheng, Qi-Huang
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244