Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury

被引：30
|
作者：
Leaf, David E.
Wolf, Myles [2 ]
Stern, Leonard [1 ]
机构：
[1] Columbia Univ, Dept Med, Div Nephrol, New York, NY 10027 USA
[2] Univ Miami, Miller Sch Med, Dept Med, Div Nephrol & Hypertens, Miami, FL 33136 USA
来源：
NEPHROLOGY DIALYSIS TRANSPLANTATION | 2010年 / 25卷 / 04期
关键词：
ARF; hyperparathyroidism; hyperphosphataemia; vitamin D; FIBROBLAST GROWTH FACTOR-23; PARATHYROID-HORMONE; RENAL-FAILURE; SECONDARY HYPERPARATHYROIDISM; METABOLISM; RECEPTOR; FGF23;
D O I：
10.1093/ndt/gfp682
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
Rhabdomyolysis-induced acute kidney injury (AKI) is characterized by hyperphosphataemia and hypocalcaemia. Despite appropriate secondary elevation of parathyroid hormone (PTH) in response to hypocalcaemia, rhabdo-myolysis and AKI are associated with acute deficiency of 1,25-dihydroxycholecalciferol (1,25(OH)(2)D-3), and yet, the mechanism responsible for such a deficiency remains unclear. Fibroblast growth factor 23 (FGF-23), a potent phosphaturic hormone that inhibits 25-hydroxyvitamin D-3-1 alpha-hydroxylase, could explain the deficiency of 1,25 (OH)(2)D-3 in this setting. Here, we document, for the first time, elevated levels of FGF-23 in a patient with rhabdomyolysis-induced AKI.
引用
收藏
页码：1335 / 1337
页数：3
相关论文
共 50 条
  • [1] IMMUNOLANDSCAPING OF RHABDOMYOLYSIS-INDUCED ACUTE KIDNEY INJURY
    Rao, Snigdha
    Casemayou, Audrey
    Buleon, Marie
    Feuillet, Guylene
    Riant, Elodie
    Zakaroff-Girard, Alexia
    Martins, Frederic
    Gonzalez-Fuentes, Ignacio
    Blache, Jean Sebastien Saulnier
    Schanstra, Joost
    Belliere, Julie
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2022, 37 : I197 - I197
  • [2] Rhabdomyolysis-Induced Acute Kidney Injury and Kidney Protection with Melatonin
    Zamorskii I.I.
    Shchudrova T.S.
    Dudka E.A.
    Biophysics, 2019, 64 (5) : 804 - 807
  • [3] Amelioration of Rhabdomyolysis-Induced Acute Kidney Injury by Ademetionine
    Zamorskii I.I.
    Drachuk V.M.
    Shchudrova T.S.
    Goroshko O.M.
    Kopchuk T.G.
    Biophysics, 2019, 64 (5) : 799 - 803
  • [4] RHABDOMYOLYSIS-INDUCED ACUTE KIDNEY INJURY (AKI) IN A CANCER PATIENT EXPOSED TO DENOSUMAB
    Neyra, Javier A.
    Vaidya, Omkar
    Tran, Nancy
    Parhizghar, Amin
    Hendricks, Allen
    Vazquez, Miguel
    AMERICAN JOURNAL OF KIDNEY DISEASES, 2013, 61 (04) : A70 - A70
  • [5] Rhabdomyolysis-Induced Acute Renal Injury in a Schizophrenic Patient
    Tiglis, Mirela
    Hurmuzache, Tudor
    Bologa, Cristina
    Neagu, Tiberiu Paul
    Mirea, Liliana
    Grintescu, Ioana Marina
    JOURNAL OF CRITICAL CARE MEDICINE, 2020, 6 (04): : 249 - 252
  • [6] The Antioxidant Activity of Ceruloplasmin in Rhabdomyolysis-Induced Acute Kidney Injury
    Zamorskii I.I.
    Unguryan T.M.
    Melnichuk S.P.
    Biophysics, 2019, 64 (6) : 1003 - 1006
  • [7] The role of complement activation in rhabdomyolysis-induced acute kidney injury
    Huang, XuDong
    Zhao, Wei
    Zhang, LiXia
    Yang, XinJun
    Wang, LiHui
    Chen, YunShuang
    Wang, JingHua
    Zhang, Chao
    Wu, GuangLi
    PLOS ONE, 2018, 13 (02):
  • [8] Rhabdomyolysis-induced acute kidney injury in a patient with undifferentiated connective tissue disease A case report and literature review rhabdomyolysis-induced AKI in a patient with UCTD
    Mai, Hongxia
    Zhao, Yuliang
    Salerno, Stephen
    Li, Yi
    Yang, Letian
    Fu, Ping
    MEDICINE, 2019, 98 (30)
  • [9] RHABDOMYOLYSIS-INDUCED RESISTANT HYPERCALCEMIA IN ACUTE KIDNEY INJURY (AKI)
    Das, Amit
    Houjeij, Nourhan
    Miyata, Kana
    Edwards, John C.
    Bellorin-Font, Ezequiel
    AMERICAN JOURNAL OF KIDNEY DISEASES, 2025, 85 (04)
  • [10] Rhabdomyolysis-induced acute kidney injury in a patient with non-compliance to levothyroxine therapy
    Ghayur, Ayesha
    Elahi, Qurrat
    Patel, Chinmay
    Raj, Rishi
    ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS, 2021,
12345