Periodontal regeneration with 0.3 % basic fibroblast growth factor (FGF-2) for a patient with aggressive periodontitis: a case report

被引：5
|
作者：
Yoshinuma, Naoto [1 ,2 ]
Koshi, Ryosuke [1 ,2 ]
Kawamoto, Kazuhiro [1 ]
Idesawa, Masataka [3 ]
Sugano, Naoyuki [1 ,2 ]
Sato, Shuichi [1 ,2 ]
机构：
[1] Nihon Univ, Sch Dent, Dept Periodontol, Tokyo 1018310, Japan
[2] Nihon Univ, Sch Dent, Dent Res Ctr, Div Adv Dent Treatment, Tokyo 1018310, Japan
[3] Shunyokai Sakura Dent Off, Chiba, Japan
来源：
JOURNAL OF ORAL SCIENCE | 2016年 / 58卷 / 01期
关键词：
FGF-2; periodontal regeneration; aggressive periodontitis; clinical trial; TISSUE REGENERATION; DEFECTS; THERAPY; BFGF;
D O I：
10.2334/josnusd.58.137
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
This case report describes the clinical efficacy of treatment with basic fibroblast growth factor (FGF-2) for periodontal regeneration. A patient with aggressive periodontitis participated in a clinical trial involving administration of 0.3% FGF-2 in comparison with a placebo control. To evaluate the efficacy of FGF-2, standardized radiographs were taken before surgery and at 12, 24, and 36 weeks after FGF-2 treatment. The rate of increase in alveolar bone height was 86.9% at 36 weeks. The 6-year postoperative radiograph showed significant development of alveolar bone in comparison with the first visit. FGF-2 treatment may be effective for periodontal regeneration in cases of aggressive periodontitis.
引用
收藏
页码：137 / 140
页数：4
相关论文
共 50 条
  • [1] Periodontal tissue regeneration by signaling molecule(s): what role does basic fibroblast growth factor (FGF-2) have in periodontal therapy?
    Murakami, Shinya
    PERIODONTOLOGY 2000, 2011, 56 : 188 - 208
  • [2] Action Mechanism of Fibroblast Growth Factor-2 (FGF-2) in the Promotion of Periodontal Regeneration in Beagle Dogs
    Nagayasu-Tanaka, Toshie
    Anzai, Jun
    Takaki, Shu
    Shiraishi, Noriko
    Terashima, Akio
    Asano, Taiji
    Nozaki, Takenori
    Kitamura, Masahiro
    Murakami, Shinya
    PLOS ONE, 2015, 10 (06):
  • [3] Basic fibroblast growth factor(FGF-2) in mouse tooth morphogenesis
    Russo, LG
    Maharajan, P
    Maharajan, V
    GROWTH FACTORS, 1998, 15 (02) : 125 - +
  • [4] Basic fibroblast growth factor (FGF-2) signal interruption in arterial injury
    Golden, MA
    JOURNAL OF VASCULAR SURGERY, 2001, 33 (06) : 1308 - 1309
  • [5] The regulation of basic fibroblast growth factor (FGF-2) through limited bioavailability
    Baird, A
    GROWTH FACTORS AND WOUND HEALING: BASIC SCIENCE AND POTENTIAL CLINICAL APPLICATIONS, 1997, : 27 - 36
  • [6] Ischemia increases the angiogenic potency of basic fibroblast growth factor (FGF-2)
    Angel, MF
    MICROSURGERY, 1996, 17 (08) : 457 - 458
  • [7] Regeneration of periodontal tissues by basic fibroblast growth factor
    Murakami, S
    Takayama, S
    Ikezawa, K
    Shimabukuro, Y
    Kitamura, M
    Nozaki, T
    Terashima, A
    Asano, T
    Okada, H
    JOURNAL OF PERIODONTAL RESEARCH, 1999, 34 (07) : 425 - 430
  • [8] Characterization of GH(3) cells overexpressing basic fibroblast growth factor (FGF-2)
    Wada, S
    Kaji, H
    Yoshimura, K
    Chihara, K
    JOURNAL OF NEUROENDOCRINOLOGY, 1997, 9 (06) : 423 - 430
  • [9] Basic fibroblast growth factor (FGF-2) is a profibrogenic cytokine in renal fibrogenesis.
    Strutz, F
    Zeisberg, M
    Becker, V
    Muller, GA
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1996, 7 (09): : A2596 - A2596
  • [10] Testing clinical therapeutic angiogenesis using basic fibroblast growth factor (FGF-2)
    Aviles, RJ
    Annex, BH
    Lederman, RJ
    BRITISH JOURNAL OF PHARMACOLOGY, 2003, 140 (04) : 637 - 646
12345