Virus-like particles as a modular system for novel vaccines

被引：48

作者：

Lechner, F ^{[1
]}

Jegerlehner, A ^{[1
]}

Tissot, AC ^{[1
]}

Maurer, P ^{[1
]}

Sebbel, P ^{[1
]}

Renner, WA ^{[1
]}

Jennings, GT ^{[1
]}

Bachmann, MF ^{[1
]}

机构：

[1] Cytos Biotechnol AG, CH-8952 Schlieren, Switzerland

来源：

INTERVIROLOGY | 2002年 / 45卷 / 4-6期

关键词：

virus-like particles; vaccine; antibody response; self antigen; adjuvant; tolerance; therapy;

D O I：

10.1159/000067912

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Induction of protective immune responses with recombinant antigens is a major challenge for the vaccine industry. Here we present a molecular assembly system that renders antigens of choice highly repetitive. Using this method, efficient antibody responses may be induced in the absence of adjuvants resulting in protection from viral infection and allergic reactions. Copyright (C) 2003 S. Karger AG, Basel.

引用

页码：212 / 217

页数：6

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