Artificial Neural Network Correlation and Biostatistics Evaluation of Physiological and Molecular Parameters in Healthy Young Individuals Performing Regular Exercise

被引：2

作者：

Garai, Kitti ^{[1
,2
]}

Adam, Zoltan ^{[1
,2
]}

Herczeg, Robert ^{[3
]}

Katai, Emese ^{[2
,4
]}

Nagy, Tamas ^{[2
,4
]}

Pal, Szilard ^{[5
]}

Gyenesei, Attila ^{[3
]}

Pongracz, Judit E. ^{[1
,2
]}

Wilhelm, Marta ^{[6
]}

Kvell, Krisztian ^{[1
,2
]}

机构：

[1] Univ Pecs, Fac Pharm, Dept Pharmaceut Biotechnol, Pecs, Hungary

[2] Univ Pecs, Szentagothai Res Ctr, Wnt Signaling Res Grp, Pecs, Hungary

[3] Univ Pecs, Szentagothai Res Ctr, Bioinformat Res Grp, Pecs, Hungary

[4] Univ Pecs, Dept Lab Med, Pecs, Hungary

[5] Univ Pecs, Fac Pharm, Dept Pharmaceut Technol & Biopharm, Pecs, Hungary

[6] Univ Pecs, Fac Sci, Inst Sport Sci & Phys Educ, Pecs, Hungary

来源：

FRONTIERS IN PHYSIOLOGY | 2019年 / 10卷

关键词：

aging; physical activity; responsiveness; prediction; prevention; PREVENTION; METABOLISM; INSIGHT; DISEASE;

D O I：

10.3389/fphys.2019.01242

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Studies support that regular physical activity (PA) decelerates senescence-related decline of physiological and molecular parameters in the elderly. We have addressed the other end of this spectrum: healthy and young, inactive individuals participated in a 6-month long personal trainer-guided lifestyle program. We have measured physiological and molecular parameters (differentiating high- and low responders) and their correlation with PA (sedentary status). Cluster analysis helped to distinguish individuals with high- or low PA and differentiate high- and low-responders of each parameter. The assessed cardiovascular parameters (heart rate, blood pressure, 6-min walking distance, relative VO(2)max), body composition parameters (body fat and muscle mass percentage) metabolic parameters (glucose, insulin, HDL, LDL), immune parameters (cortisol, CRP, lymphocyte counts, hTREC) all showed improvement. Artificial neural network analysis (ANN) showed correlation efficiencies of physiological and molecular parameters using a concept-free approach. ANN analysis appointed PA as the mastermind of molecular level changes. Besides sedentary status, insulin and hTREC showed significant segregation. Biostatistics evaluation also supported the schism of participants for their sedentary status, insulin concentration and hTREC copy number. In the future ANN and biostatistics, may predict individual responses to regular exercise. Our program reveals that high responder individuals of certain parameters may be low responders of others. Our data show that moderate regular PA is essential to counteract senescence in young and healthy individuals, despite individual differences in responsiveness. Such PA may not seem important in the everyday life of young and healthy adults, but shall become the base for healthy aging.

引用

页数：11