Society for Biomolecular Sciences-16th Annual Conference & Exhibition Advancing the Science of Drug Discovery 11-15 April 2010, Phoenix, AZ, USA

被引：0

作者：

Napper, Andrew D. ^{[1
]}

机构：

[1] Nemours Ctr Childhood Canc Res, Wilmington, DE 19803 USA

来源：

IDRUGS | 2010年 / 13卷 / 06期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The 16th annual conference of the Society for Biomolecular Sciences, held in Phoenix, AZ, USA, included topics covering new drug discovery efforts in the field of oncology research. This conference report highlights selected presentations on developing inhibitors of biochemical and cell-based targets, particularly PI3K and Hsp90; the effect of protein domain structure, inhibitor binding kinetics and phosphorylation state on inhibitor potency; and screening strategies for DNA repair, senescence and synthetic lethality. Investigational drugs discussed include GDC-0941 (Genentech Inc), NVP-AUY-922 (Novartis AG) and olaparib (AstraZeneca).

引用

页码：372 / 375

页数：4