Electrospun pectin/modified copper-based metal-organic framework (MOF) nanofibers as a drug delivery system

Pectin has been regarded as a drug carrier accelerating the healing process due to its bioactivities, abundance and lower cost of resources. However, a big challenge related to its practical application is its poor mechanical strength. In this study the modified Cu-based MOF containing Folic acid was synthesized and incorporated in the suitable pectin electrospun nanofibers which not only improved the copper ions release behavior but also made the fiber mat stronger, antibacterial and induce angiogenesis, fibroblast migration, and proliferation due to loaded copper ions and folic acid. The nanofibers composing of 75% pectin and 4000 kDa-PEO were chosen after morphological and mechanical characterization. Finally, the effect of MOF incorporation on the nano-composite samples was characterized in terms of morphological, physiochemical and biological properties. The nanofibrous mats were evaluated by tensile testing, antibacterial and cytotoxicity. The release behavior of copper ions and folic acid was controlled and their burst release alleviated reducing cytotoxicity in vitro. It was found that the Young's moduli of the pectin nanofibers were improved to 19.13 MPa by the addition of Cu-based MOFs. Moreover, nanocomposite pectin nanofibers were found to be antibacterial and biocompatible. These results demonstrate that MOF-contained pectin nanofibers are promising for biomedical applications. (C) 2021 Elsevier B.V. All rights reserved.