Recent advances of thiazole hybrids in biological applications

被引:79
|
作者
Gumus, Mehmet [1 ,2 ]
Yakan, Mehmet [1 ]
Koca, Irfan [1 ]
机构
[1] Bozok Univ, Fac Art & Sci, Dept Chem, Yozgat, Turkey
[2] Bozok Univ, Akdagmadeni Hlth Coll, Yozgat, Turkey
关键词
anticancer; biological activity; hybride compounds; thiazole; AGENTS SYNTHESIS; ANTIINFLAMMATORY EVALUATION; PHARMACOLOGICAL EVALUATION; ANTIMICROBIAL AGENTS; INHIBITORS; DESIGN; DERIVATIVES; ANTIBACTERIAL; DOCKING; POTENT;
D O I
10.4155/fmc-2018-0196
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Thiazoles have attracted much synthetic interest due to their wide variety of biological properties and are important members of heterocyclic compounds. In recent years, studies on the synthesis of thiazole compounds have been increasing because of the properties of this core. In particular, the hybrid structures in which the thiazole ring and the other nuclei are linked have gained popularity. Hybrid structures are formed by the combination of different groups of chemical reactivity and biological activity characteristics. In this review, we highlight recent developments related to hybrid structures containing a thiazole core, recently developed as anticancer, antibacterial, anti-inflammatory, analgesic, anti-tubercular, antialzheimer and antidiabetic compounds. [GRAPHICS] .
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页码:1979 / 1998
页数:20
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