Identification of seven metabolites of oxyresveratrol in rat urine and bile using liquid chromatography/tandem mass spectrometry

被引：20

作者：

Huang, Huilian ^{[1
,2
]}

Chen, Guangtong ^{[1
]}

Lu, Zhiqiang ^{[1
]}

Zhang, Jinqiang ^{[1
]}

Guo, De-An ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China

[2] Jiangxi Univ Tradit Chinese Med, Minist Educ, Key Lab Modern Preparat TCM, Nanchang 330004, Peoples R China

来源：

BIOMEDICAL CHROMATOGRAPHY | 2010年 / 24卷 / 04期

关键词：

oxyresveratrol; metabolite; LC-MS/MS; SPE; MORUS-ALBA; RESVERATROL; MECHANISM;

D O I：

10.1002/bmc.1309

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) is a major compound isolated from Smilax china, a Chinese herbal medicine. The rat urine and bile samples were pretreated by solid-phase extraction method after oral administration at a dose of 100 mg/kg of oxyresveratrol. Seven metabolites were identified by LC-MS/MS method with electrospray ionization in negative ion mode. The results indicated that main metabolites of oxyresveratrol were monoglucuronided and monosulfated oxyresveratrol. Based on the results, the metabolic pathway of oxyresveratrol in rat urine and bile was proposed. Copyright (C) 2009 John Wiley & Sons, Ltd.

引用

页码：426 / 432

页数：7

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