Synthesis and biological activity of novel 1,3,4-oxadiazole derivatives containing a pyrazole moiety

被引：18

作者：

Yu, Wei ^{[1
]}

Zhai, Zhi-Wen ^{[1
]}

Wedge, David E. ^{[2
]}

Duke, Stephen O. ^{[2
]}

Wu, Hong-Ke ^{[1
]}

Weng, Jian-Quan ^{[1
]}

Tan, Cheng-Xia ^{[1
]}

Zhang, Yong-Gang ^{[3
]}

Liu, Xing-Hai ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China

[2] USDA ARS, Nat Prod Utilizat Res Unit, University, MS 38677 USA

[3] Qilu Univ Technol, Biol Inst, Shandong Acad Sci, Jinan, Shandong, Peoples R China

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2019年 / 45卷 / 12期

关键词：

Oxadiazole; Pyrazole; Synthesis; Fungicide; Herbicide; CRYSTAL-STRUCTURE; NEMATOCIDAL ACTIVITY; ANTIFUNGAL ACTIVITY; FUNGICIDAL ACTIVITY; 1,2,3-THIADIAZOLE DERIVATIVES; ANTIMICROBIAL ACTIVITY; HERBICIDAL ACTIVITY; EFFICIENT SYNTHESIS; ONE-POT; HYDRAZONE;

D O I：

10.1007/s11164-019-04015-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several new 1,3,4-oxadiazole derivatives containing a pyrazole ring were designed and synthesized from ethyl acetoacetate and triethyl orthoformate as starting materials via multi-step reactions. The compound structures were confirmed by melting point, H-1 NMR and HRMS. They were evaluated for fungicidal and herbicidal activities. Four of the compounds exhibited moderate fungicidal activity against Colletotrichum species. Most of the compounds had moderate-to-good activity as a herbicide.

引用

页码：5989 / 6001

页数：13

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