Biologic Therapies for Immunoglobulin E-mediated Food Allergy and Eosinophilic Esophagitis

被引：5

作者：

Otani, Iris M. ^{[1
]}

Nadeau, Kari C. ^{[1
,2
]}

机构：

[1] Stanford Univ, Dept Med, Sean N Parker Ctr Allergy & Asthma Res, Palo Alto, CA USA

[2] CCSR 3215c,269 Campus Dr, Stanford, CA 94305 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2017年 / 37卷 / 02期

关键词：

Food allergy; Eosinophilic esophagitis; Anti-IgE; Anti-IL-5; Anti-IL-13; QAX576; 00000459; THYMIC STROMAL LYMPHOPOIETIN; ANTI-IL-5 MEPOLIZUMAB THERAPY; HUMAN EPITHELIAL-CELLS; ANTI-IGE THERAPY; FC-EPSILON-RI; AIRWAY INFLAMMATION; ATOPIC-DERMATITIS; DOUBLE-BLIND; COWS MILK; ORAL DESENSITIZATION;

D O I：

10.1016/j.iac.2017.01.010

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Immunoglobulin (Ig) E-mediated food allergy and eosinophilic esophagitis (EoE) are chronic, allergen-mediated disorders characterized by an aberrant TH2 immune response. The development and investigation of biologics for the treatment of IgE-mediated food allergy and eosinophilic esophagitis have provided further insight into the pathophysiology and management of these disorders. This article provides an overview of biologic therapies that are being investigated or have potential as treatments for IgE-mediated food allergy and eosinophilic esophagitis. Identification of EoE phenotypes that are responsive to biologics and investigation of biologics combined with other therapies may help elucidate a role for biologics in EoE.

引用

页码：369 / +

页数：29

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