From cholapod to cholaphane transmembrane anion carriers: accelerated transport through binding site enclosure

被引：54
|
作者：
Judd, Luke W. [1 ]
Davis, Anthony P. [1 ]
机构：
[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 13期
基金：
英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;
关键词：
STEROID-BASED RECEPTORS; CHLORIDE TRANSPORT; MEMBRANE TRANSPORTERS; CHEMISTRY; CHANNELS; EXTRACTION; SCAFFOLDS; COMPLEX; ACIDS; ASSAY;
D O I：
10.1039/b927005a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cyclosteroidal "cholaphane" anion transporters show increased activities compared to acyclic "cholapod" analogues.
引用
收藏
页码：2227 / 2229
页数：3
相关论文
共 50 条
  • [1] Structure-Activity Relationships in Cholapod Anion Carriers: Enhanced Transmembrane Chloride Transport through Substituent Tuning
    McNally, Beth A.
    Koulov, Atanas V.
    Lambert, Timothy N.
    Smith, Bradley D.
    Joos, Jean-Baptiste
    Sisson, Adam L.
    Clare, John P.
    Sgarlata, Valentina
    Judd, Luke W.
    Magro, Germinal
    Davis, Anthony P.
    CHEMISTRY-A EUROPEAN JOURNAL, 2008, 14 (31) : 9599 - 9606
  • [2] Towards predictable transmembrane transport: QSAR analysis of anion binding and transport
    Busschaert, Nathalie
    Bradberry, Samuel J.
    Wenzel, Marco
    Haynes, Cally J. E.
    Hiscock, Jennifer R.
    Kirby, Isabelle L.
    Karagiannidis, Louise E.
    Moore, Stephen J.
    Wells, Neil J.
    Herniman, Julie
    Langley, G. John
    Horton, Peter N.
    Light, Mark E.
    Marques, Igor
    Costa, Paulo J.
    Felix, Vitor
    Frey, Jeremy G.
    Gale, Philip A.
    CHEMICAL SCIENCE, 2013, 4 (08) : 3036 - 3045
  • [3] Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport
    Spooner, Michael J.
    Li, Hongyu
    Marques, Igor
    Costa, Pedro M. R.
    Wu, Xin
    Howe, Ethan N. W.
    Busschaert, Nathalie
    Moore, Stephen J.
    Light, Mark E.
    Sheppard, David N.
    Felix, Vitor
    Gale, Philip A.
    CHEMICAL SCIENCE, 2019, 10 (07) : 1976 - 1985
  • [4] Tilting and Tumbling in Transmembrane Anion Carriers: Activity Tuning through n-Alkyl Substitution
    Edwards, Sophie J.
    Marques, Igor
    Dias, Christopher M.
    Tromans, Robert A.
    Lees, Nicholas R.
    Felix, Vitor
    Valkenier, Hennie
    Davis, Anthony P.
    CHEMISTRY-A EUROPEAN JOURNAL, 2016, 22 (06) : 2004 - 2011
  • [5] Simple squaramide receptors for highly efficient anion binding in aqueous media and transmembrane transport
    Picci, Giacomo
    Kubicki, Maciej
    Garau, Alessandra
    Lippolis, Vito
    Mocci, Rita
    Porcheddu, Andrea
    Quesada, Roberto
    Ricci, Pier Carlo
    Scorciapino, M. Andrea
    Caltagirone, Claudia
    CHEMICAL COMMUNICATIONS, 2020, 56 (75) : 11066 - 11069
  • [6] Diffusion-Influenced Transport of Ions across a Transmembrane Channel with an Internal Binding Site
    Zhou, Huan-Xiang
    JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2010, 1 (13): : 1973 - 1976
  • [7] Location of a permeant anion binding site in the cystic fibrosis transmembrane conductance regulator chloride channel pore
    Hussein N. Rubaiy
    Paul Linsdell
    The Journal of Physiological Sciences, 2015, 65 : 233 - 241
  • [8] Location of a permeant anion binding site in the cystic fibrosis transmembrane conductance regulator chloride channel pore
    Rubaiy, Hussein N.
    Linsdell, Paul
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2015, 65 (03): : 233 - 241
  • [9] Anion transport through polymer inclusion membranes facilitated by transition metal containing carriers
    Gardner, Joseph S.
    Peterson, Quinn P.
    Walker, Jedediah O.
    Jensen, Bryce D.
    Adhikary, Bibhutosh
    Harrison, Roger G.
    Lamb, John D.
    JOURNAL OF MEMBRANE SCIENCE, 2006, 277 (1-2) : 165 - 176
  • [10] Carboxylate anion diminishes chloride transport through a synthetic, self-assembled transmembrane pore
    You, Lei
    Ferdani, Riccardo
    Li, Ruiqiong
    Kramer, Joseph P.
    Winter, Rudolph Ernst K.
    Gokel, George W.
    CHEMISTRY-A EUROPEAN JOURNAL, 2008, 14 (01) : 382 - 396
12345