Circulating antioxidant levels in systemic lupus erythematosus patients: a systematic review and meta-analysis

被引：13
|
作者：
Sam, Napoleon Bellua [1 ,2 ]
Li, Bao-Zhu [1 ,2 ]
Leng, Rui-Xue [1 ,2 ]
Pan, Hai-Feng [1 ,2 ]
Ye, Dong-Qing [1 ,2 ]
机构：
[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 81 Meishan Rd, Hefei, Anhui, Peoples R China
[2] Anhui Prov Key Lab Major Autoimmune Dis, 81 Meishan Rd, Hefei, Anhui, Peoples R China
来源：
BIOMARKERS IN MEDICINE | 2019年 / 13卷 / 13期
基金：
中国国家自然科学基金;
关键词：
catalase; glutathione peroxidase; meta-analysis; superoxide dismutase; systemic lupus erythematosus; ESSENTIAL FATTY-ACIDS; RHEUMATOID-ARTHRITIS; OXIDATIVE STRESS; GLUTATHIONE LEVELS; ALPHA-TOCOPHEROL; REDOX STATE; PATHOGENESIS; CATALASE; DISEASE; DAMAGE;
D O I：
10.2217/bmm-2019-0034
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: To derive a precise estimation on plasma/serum level of SOD, GPx, CAT and GSH levels in systemic lupus erythematosus (SLE) patients. Methods: A total of 36 articles from electronic databases were finally included with 1120 SLE patients and 1024 healthy controls considered for antioxidant levels. Results: The levels of CAT and GSH were significantly lower, while SOD and GPx levels were slightly lower in patients with SLE compared with healthy controls. Subgroup analysis indicated that Arabs, ages >= 40 and SLE diseases activity index <6 had a significant association of SOD and CAT levels with SLE patients. Conclusion: The results demonstrated a significant lower CAT and GSH levels and also revealed no significant difference for SOD and GPx levels in SLE patients.
引用
收藏
页码：1137 / 1152
页数：16
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