Hypergravity affects morphology and function in microvascular endothelial cells

被引：17
|
作者：
Monici, Monica
Marziliano, Nicola
Basile, Venere
Pezzatini, Silvia
Romano, Giovanni
Conti, Antonio
Morbidelli, Lucia
机构：
[1] Univ Florence, CEO, Dept Clin Physiopathol, I-50139 Florence, Italy
[2] San Matteo Hosp, IRCCF, I-27100 Pavia, Italy
[3] Univ Florence, Dept Clin Physiopathol, I-50139 Florence, Italy
[4] Univ Siena, Pharmacol Sect, Dept Biol Mol, I-53100 Siena, Italy
来源：
MICROGRAVITY SCIENCE AND TECHNOLOGY | 2006年 / 18卷 / 3-4期
关键词：
D O I：
10.1007/BF02870417
中图分类号：
V [航空、航天];
学科分类号：
08 ; 0825 ;
摘要：
cardiovascular diseases are major health problems in astronauts and pilots. The basic problem in cardiovascular diseases is the loss of function by vascular endothelium. It has been demonstrated that changes in inertial conditions (i.e. hypo- and hypergravity) can affect both phenotypic and genotypic expression in endothelial cells. This report describes the effects observed in endothelial cells from coronary post-capillary venules after repeated exposures to hypergravity conditions, alternating with recovery periods. The results showed changes in gene expression, cell energy metabolism, morphology and cytoskeleton organization.
引用
收藏
页码：234 / 238
页数：5
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