Toxicity of cisplatin to the central nervous system of male rabbits

被引：23
|
作者：
Namikawa, K
Asakura, M
Minami, T
Okazaki, Y
Kadota, E
Hashimoto, S
机构：
[1] Kinki Univ, Fac Pharmaceut Sci, Dept Clin Chem, Osaka 5778502, Japan
[2] Kishiwada Municipal Hosp, Div Pathol, Osaka 5968501, Japan
[3] Kinki Univ, Sch Med, Dept Pathol 2, Osaka 5898511, Japan
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 2000年 / 74卷 / 03期
关键词：
cisplatin (CDDP); cytotoxicity; brain; rabbit; CDDP clearance; blood-brain barrier (BBB);
D O I：
10.1385/BTER:74:3:223
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cytotoxic effects of platinum (Pt) were studied by intraparenchymal injection of 1 mg of cisplatin (CDDP) in male rabbits. Time-serial plasma Pt levels were used as CDDP clearance indices in brain and kidney tissues. The tissue samples were also examined histologically. Changes in the blood-brain barrier (BBB) were evaluated by horseradish peroxidase (HRP) extravasation. In the brain infusion group, Pt was detected in the plasma 30 min after the start of infusion. In the kidney, Pt was detected after 10 min of CDDP injection. The maximum plasma concentration of Pt in the brain group showed diffuse edema, neuronal necrosis, karyolysis, and HRP extravasation around the injection site. In contrast, the histological damage to kidneys was minimal. The results presented here show that direct infusion of CDDP caused the most extensive cytotoxicity in the brain. The low clearance rate of CDDP from the brain and BBB disruption may explain this behavior.
引用
收藏
页码：223 / 235
页数：13
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