Background: Novel coronavirus disease 2019 (COVID-19) is a serious infectious respiratory disease widespread worldwide. Nurses are the front-line staff in contact with infected patients and play a key role in treating patients and controlling the epidemic. The purpose of this study was to share our nursing team's experience in the treatment of COVID-19 and provide clinical guidance. Methods: Detail nursing system arrangement was laid down: (I) reasonable division of ward channel was built; (II) effectively arranged human nursing resources and establishing special groups, including Training group, Critical patients nursing group, Quality control group, Epidemic preventive measures group, and Logistics support group; (III) optimize nursing workflow and establish various rules and regulations; (IV) scientific scheduling and humanized management; (V) pay attention to psychological support and adopt humanized management. The pre-job preparation, treatment results, and medical staff infection number were recorded. Results: Fifty-four intensive care nurses all passed the training with an average score of 99.75 +/- 0.13. One patient was dead, and 22 patients were discharged smoothly. The average length of stay was 9.12 days. The medical staff was not infected. Conclusions: The treatment center was set up and functioning rapidly, safely, and orderly by implementing an emergency management strategy. The goal of a high rescue rate, low mortality, and no medical staff infection was achieved. This nursing system could be applied in COVID-19 patient treatment.